Background: Tuberculosis is an airborne infection that causes lung damage, and it is particularly harmful to patients with weakened immune systems or other health problems. Allopathic medications are associated with development of cross resistance or multidrug resistance in diseases such as TB, making treatment more difficult. In this case, Herbal remedies are the most effective in treating this disease. Medicinal plants with antituberculotic qualities provide pharmacists with a new supply of medicine, allowing them to create novel drugs depending on their active constituents or intermediate metabolites. Objective: Many recent studies have shown that ayurvedic medicines can reduce mortality dramatically when administered in such situations because they interact with the body's natural environment. Ayurvedic medicine is growing in popularity due to its low toxicity study and lack of side effects when compared to allopathic treatments. Conclusion: Considering botanical categorization and anti-tubercular action, Anti-tubercular medicinal herbs have been chosen from scientific literature for this review. A primary objective of this study is to highlight antituberculosis plants, their chemical compounds, and their anti-tubercular properties.

The numbers of products based on new drug delivery systems have considerably increased in the past few years, and this growth is projected to carry on in the future. These bio-pharmaceuticals present challenges to drug delivery system because of their different nature and difficulty in delivery through conventional routes. Therefore, further research will focus on the delivery of these complex molecules through different routes, including nasal, pulmonary, vaginal, rectal, etc. The intend of the study was to formulate and evaluate ethosomes of Sesbania grandiflora leaves which may transport the drug to targeted site more efficiently than marketed gel preparation and also overcome the problems related with oral administration of drug. Trans-dermal drug delivery is a technique which can be exploited to overcome the variables, which could affect the oral absorption of drugs such as pH, food intake and gastrointestinal motility. As compared to liposome or hydro-alcoholic solution ethosomal systems were much more capable at delivering a fluorescent probe to the skin in terms of quantity and depth. The formulations were prepared with ethanol, lecithin, propylene glycol, and glycerol and were evaluated. The lecithin (phospholipids) used as a vesicles forming component, polyglycol and ethanol used as a skin penetration enhancer. The drug released of formulated ethosomal gel was 4-5 times improved as compared to non ethosomal gel which directly achieves unparalleled flexibility in formulation. Ethosomal gel successfully addresses the issues relating to the drug delivery of poorly water-soluble drugs, peptides, potent drugs and the release of multi-drugs.

World facing pandemic challenges of SARS-Co-2 (Severe Acute Respiratory Syndrome Corona Virus 2). Tyrrell and Bynoe identified first strain of human corona virus in 1965. Infection was originated from Wuhan city of China on November 2019. Virus officially named as COVID-19 which causes respiratory tract infections in humans. Preliminary symptoms like chest pain with difficulty in breathing, reduced in systemic oxygen level, cough and fever. At present, the majority of the pharmaceutical companies were in race to developing antiviral drug and vaccines against COVID-19. Industries conducting the experiment and clinical trial of various vaccines to ensure effectiveness and safety on human. Several of them were documentation for patent, authorization of clinical trial and marketing. We provide an overview of Covid-19 history, types of vaccine and mechanism of actions, current future therapeutic drugs and patents. Relative with the mechanism of actions such as inactivated vaccine, vector vaccines, DNA and RNA based vaccine and antiviral drugs already entered in (Phase II and III) clinical trials. The systemic study specified brief summary of various vaccines. Current status of clinical trial, safety and effectiveness according to ICH guidelines. A major adverse interaction with their toxicity study. The information of approved which give opportunity for upcoming scientist to improve the quality, and minimize the adverse effects. Scientist may face challenges during the post marketing clinical trial. This pandemic has provided various scopes for researchers to develop vaccine and antiviral drugs.

Cancer is a mutagenic disorder which causes uncontrollable growth of cells in the body. This uncontrolled growth further produces the tumor. This action stimulates the immune system which can prevent or promote tumor growth. Novel strategies for treatment of cancer are also to target this immune system. Many conventional treatments are restricted for the particular organ tumor. So, these therapies are no more in use. Cancer is the second most fatal disorder worldwide. Therefore, there is always a great need for research for the treatment strategies for cancer. Treatment of cancer is a serious topic to be discussed worldwide. Our study shows the novel treatments (e.g., target therapy, Immunotherapy, Hormones therapy) for different categories of cancer. Very first we discussed the description of different types of cancer and then its treatment strategies. We also discussed the Novel therapy systems for cancer that are in view of more definite comprehension over the tumor science depending on most recent new innovation and are expected to improve the current treatment result for patients with disease. However, a significant number of these methodologies still have one normal and basic issue, being restricted for tumor cells.

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