Hohe Konzentrationen von Procalcitonin wurden bei verschiedenen bakteriellen Infektionen und der Sepsis gefunden. Bei 162 Patienten mit einer Peritonitis wurden dieser Parameter untersucht. Im Vergleich zu Scoringsystemen, Standardlaborwerten und anderen Zytokinen (z.B. Tumor-Nekrose-Faktor, Interleukin-6) war Procalcitonin eng mit der Beherrschung der infektiösen oder septischen Komplikationen und einer erfolgreichen Therapie korreliert.

The Denver Developmental Screening Test was given to 373 disadvantaged black children attending preschool nursery classes in a large urban area. Findings are presented and discussed. Primary emphasis is on the need for early recognition of developmental failures and the establishment of remedial classes within existing preschool programs. Cultural stereotyping is viewed as one obstruction to early identification of learning deficits.

No abstract

. Cardiovasch I n s t i t u t e , Univ. of C a l i f o r n i a , San Francisco, Ca. We have developed an i n t e r c o s t a l r e t r a c t o m e t e r f o r t h e nonnvasive e s t i m a t i o n of i n t r a p l e u r a l p r e s s u r e . I t c o n s i s t s of a cored l u c i t e d i s c covered by a t h i n a c e t a t e membrane. The scord l i n e s and t h e membrane w i t h t h e d i s c form a small space which s f i l l e d w i t h l i q u i d . The membrane i s a t t a c h e d t o t h e s k i n and ny r e t r a c t i v e f o r c e a p p l i e d t o t h e device by t h e i n t e r c o s t a lpace is t r a n s l a t e d i n t o p r e s s u r e changes i n t h e l i q u i d , detected y a 1' 50A Statham s t r a i n guage.Twelve s t u d i e s were performed i n 3 i n f a n t s with h y a l i n e memrane d i s e a s e , averaging 1180 g weight, and 30 wks G.A. Comparion w i t h estimated i n t r a p l e u r a l p r e s s u r e was made using an esohageal b a l l o o n placed i n t h e mid-thorax.The r e t r a c t o m e t e r was a l i b r a t e d by measuring t h e occluded airway p r e s s u r e , which ollowed changes i n esophageal p r e s s u r e t o w i t h i n ? 1 cm H20 over range of 30 cm H20. This c a l i b r a t i o n method a l s o allows f o r he d e t e c t i o n of a r t i f a c t s due t o i n a p p r o p r i a t e p o s i t i o n i n g of he device. The r e g r e s s i o n l i n e of r e t r a c t o m e t e r output vs esohageal p r e s s u r e had an average s l o p e of 0.4 and p r e d i c t e d t h e sophageal p r e s s u r e t o w i t h i n ? 1.7 cm Hz0 (95% confidence l i m i t ) I n using t h e device, c a r e must be taken t o e l i m i n a t e a r t i f a c t s ue t o movement of t h e instrument and f a u l t y attachment t o t h e h e s t w a l l . The response of t h e device i s a t t e n u a t e d by subcutneous t i s s u e , roughly i n proportion t o t h e t h i c k n e s s of t h e i s s u e . (Supported i n p a r t by Contract HR 6-2093) VALUATION OF ANTIBIOTIC THERAPY I N PATIENTS WITH CF.; Braverman, S h i r l e y ; Laraya-Cuasay , Helen; Yasmin, Nasira Temple Univ. o f P e d i a t r i c s , S t . C h r i s t o p h e r ' s Hosp i t a l f o r Children, P h i l a d e l p h i a . Pa. 19133 The e f f e c t of secondary b e c t e r i a l i n f e c t i o n s of t h e bronchopulmonary system on p a t i e n t s with CF has been f i r m l y e s t a b l i s h e d and i t has been p o s s i b l e t o p a r t i a l l y c o n t r o l t h e s e i n f e c t i o n s b aggressive b r o n c h i a l drainage and e n e r g e t i c a n t i b i o t i c t h e r a p y . The t h e r a p e u t i c e f f e c t of t h e s e m o d a l i t i e s of treatment has not been evaluated q u a n t i t a t i v e l y .This study attempts t o measure t h e e f f i c a c y o f amikacin with c a r b e n i c i l l i n i n 15 p a t i e n t s (median age 14 y r s ) with pseudomona i n f e c t i o n . Subjects were scored on t h e s e v e r i t y of d i s e a s e acco r d i n g t o parameters i n c l i n i c a l ...