Malnutrition children have lower intelligence due to brain cells damage caused by oxidative stress. Seluang (Rasbora spp.) has the potential te reduce this problem. This study aimed to analyze the correlation between hydrogen peroxide (H 2 O 2) levels with malondialdehyde (MDA) levels in the brain of malnourished rats after administration of seluang.  This study used a posttest only with control group design. 30 white rats (Rattus norvegicus) made into malnutrition and divided into three groups, M: malnutrition group, P1: malnourished rats fed standard diet, P2: malnourished rats fed seluang for 4 weeks. The results showed that malnourished rats had the highest levels of H 2 O 2. ANOVA statistical tests showed a significant differences between H 2 O 2 levels (p = 0.001) and MDA levels (p = 0.001) among malnutrition group with the other groups Pearson correlation test results concluded that there was a correlation H 2 O 2 levels with MDA levels (p = 0.001, r = 0.684) as indicated by decrease of H 2 O 2 levels followed by decrease in MDA levels. This study showed a correlation between H 2 O 2 levels and MDA levels in the of malnourished rat brain fed seluang. Thus seluang can improve the condition of oxidative stress in malnourished rat brain.

Objective: Antiplatelet therapy is recommended in patients with coronary heart disease (CHD) who had the percutaneous coronary intervention (PCI) procedure to reduce major adverse cardiovascular events (MACE). There has been a lack of population-based studies that showed the superior effectiveness of ticagrelor over clopidogrel and similar studies have not been conducted in Indonesia yet. The aim of the study was to investigate the effectiveness of ticagrelor compared to clopidogrel in reducing the risk of MACE in patients with CHD after PCI. Methods:A retrospective cohort study with 1-year follow-up was conducted. 361 patients consisted of 111 patients with ticagrelor exposure and 250 patients with clopidogrel exposure. The primary outcome was MACE, defined as a composite of repeat revascularization, myocardial infarction, or all-cause death. The association between antiplatelet exposure and the MACE was analyzed with Cox proportional hazard regression, adjusted for sex, age, comorbid, PCI procedures and concomitant therapy.Results: MACE occurred in 22.7% of the subjects. Clopidogrel had a significantly higher risk of MACE compared with ticagrelor (28.8%, vs 9.0%, hazard ratio (HR): 1.96 (95% CI 1.01 to 3.81, p=0.047). There were no significant differences in risk of repeat revascularization (20.40% vs 5.40%, HR: 2.32, 95% CI 0.99 to 5.42, p = 0.05), myocardial infarction (11.60% vs 3.60%, HR: 2.08, 95% CI, 0.73 to 5.93, p = 0.17), and death (1.60% vs 1.80%, HR: 0.77, 95% CI, 0.14 to 4.25, p = 0.77). Conclusion:Clopidogrel had a higher risk of MACE compared to clopidogrel in patients with CHD after PCI, but there were no significant differences in the risk of repeat revascularization, myocardial infarction, and all-cause death.

Melastoma malabathricum L. is a type of plant naturally grows in Kalimantan that has medicinal properties. Ethanolic extract of M. malabathricum L. flower has quercetin and kaempferol contents that have antioxidant and anticancer activities. But the antioxidant and cytotoxicity activities of M. malabathricum L. fruit ethanolic extract were not known. This study measured the quercetin and kaempferol level in M. malabathricum L. fruit ethanolic extract using HPLC MS/MS, antioxidant activity using DPPH method, and cytotoxicity activity using Brine Shrimp Lethality Test (BSLT) method. Results showed the level of quercetin and kaempferol from M. malabathricum L fruit ethanolic extract are 67.78 µg/g and 43.52 µg/g, respectively. Beside, the antioxidant activity with by IC50 was 16.82±0.24 ppm and 7.38±0.41 ppm. The cytotoxicity activities of M. malabathricum L. fruit ethanolic extract and quercetin are shown by the LC50 of 313.44 ppm (95%CI 283.97-344.43) and 37.24 ppm, respectively.

Prevalence of malnutrition in Indonesia is still high although it has some potential source of nutrients. Seluang fish (Rasbora spp.) is a river fish consumed by the people of South Kalimantan, Indonesia. This study analyzed the improvement of nutritional status in the malnourished rats after treatment with Seluang Fish. The study used malnourished white rats (Rattus norvegicus) using a low protein and fat diet for 8 weeks. The rats were divided into three groups; malnourished group (M) without other dietary treatment, standard diet (P1) and seluang diet (P2) for a period of four weeks. The malnourished group was sacrificed first, and after four weeks treatment, other groups were sacrificed; blood and bones were taken for weight, protein levels, hemoglobin levels, bone length, bone calcium levels and IGF-1 levels. The results showed that the average of body weight for all the studied groups ranged between 190 to 220g. Seluang diet had the highest serum protein levels (4.388 mg/dL), hemoglobin (19.7 mg/dL) and IGF levels (388.7 ng/mL). Standard diet had the longest bone length (3.547 cm) and the highest Calcium levels of 1.68 mg/g. Based on these results, it was concluded that Seluang fish may have the potential to improve the nutritional status of malnourished rats.

levels were not significantly different (p ¼ 0.483). Group P1 and P2 were not different significantly in the serum and brain serotonin, and brain SOD levels. The brain H 2 O 2 (p < 0.001) and MDA levels (p < 0.001) were different significantly. We concluded that seluang fish diet was able to repair oxidative stress in the brains of rats due to endosulfan induction during pregnancy.