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1. A simplification of the method of Anrep et al. for the estimation of histamine in human urine is described. 2. It is not possible by this method to obtain a reliable estimation of the amount of free histamine normally present in human urine, but the effects of the administration of histamine may be followed. 3. When 133 mg. of histamine was given by mouth to three men, it was mainly conjugated histamine that appeared in the urine. 4. When 3·5‐5 mg. was infused intravenously in three men, free histamine appeared in the urine. 5. In two of these experiments no changes were detected in the histamine content of the plasma or cells obtained from the antecubital vein. It is concluded that investigations of the excretion of histamine are more likely to give information about the release of histamine in the body than investigations on venous blood.

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