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IntroductionThe primary objective of the study was to compare the serum luteinizing hormone (LH) levels in patients with hyperandrogenism on metformin and combined oral contraceptive pills. Secondarily, the study also assessed the serum testosterone, body mass index (BMI), and the time to achieve regular menstruation were also assessed.

IntroductionA condition in which uric acid levels are elevated but there are no accompanying symptoms is known as asymptomatic hyperuricemia. As a result of the disparity in opinions and findings between the studies, the guidelines regarding whether or not asymptomatic hyperuricemia should be treated are unclear. Material and methodsBetween the months of January 2017 and June 2022, this research was carried out in the community in collaboration with the internal medicine unit and the public health unit of Liaquat University of Medical and Health Sciences. After obtaining informed consent from each participant, the researchers enrolled 1,500 patients in the study who had uric acid levels that were greater than 7.0 mg/dL. These patients ranged in age from 40 to 70 years old and were of either gender. As a control group, 1,500 patients were recruited who did not have abnormally high levels of uric acid. Patients were monitored for a total of 48 months or until the occurrence of a major cardiovascular event (MACCE) or death from all causes, whichever occurred first. Death, cardiovascular mortality, non-fatal myocardial infarction, and non-fatal stroke were the four categories that made up the primary outcome, also known as MACCEs. ResultsIn the hyperuricemic group, the incidence of myocardial infarction that did not result in death was significantly higher than in the non-hyperuricemic group (1.6% vs. 0.7%; p-value, 0.04). However, the result was not significant for deaths from all causes, deaths from cardiovascular disease, or strokes that did not result in death. ConclusionAsymptomatic hyperuricemia is a potential threat to one's health that can lead to cardiovascular diseases and may go undiagnosed in some cases. It is important to remember that hyperuricemia can lead to delirious complications, so efforts should be made to perform routine monitoring and management of the condition.

BackgroundThere have been indications of a correlation between serum homocysteine (Hcy) levels and poor patient outcomes in traumatic brain injury (TBI). Thus, we aimed to explore the role of serum Hcy in influencing the outcome post TBI.

The contemporary contagious ailment is caused by one of the deadliest coronaviruses, the SARS-COV-2. This novel zoonotic entity leads to multi-organ failure and an escalating threat and turbulence all over the world. Albeit a lot of work has been done to beat this virus, it is still radiating consistently. A colossal number of antiviral drugs has been tested to overcome the current pandemic but no promising remedy. A new approach to employ drug amalgamation such as remdesivir with hydroxychloroquine and losartan would better eradicate this outbreak. For this purpose, copper nanoparticles (extracted from a Prophetic, miraculous herb Nigella sativa) would serve as excellent transporters of such kinds of drug composites. In this review, the several possible therapies available across the world will be discussed in addition to the existing evidence for each of them. This new insight would be beneficial to fight against the latest rife.