HIV/AIDS remains the greatest public health concern in the world. Nowadays HIV-AIDS is considered as a chronic disease due to the advent of highly active antiretroviral therapy. This therapy has significantly improved the status of the infected population, making HIV a manageable illness. However, recent studies suggest that exposure to antiretroviral medications may have marked adverse effects, independent of HIV status. This review article gives a note on the demerits of the therapy, major complications and metabolic abnormalities that occur as a consequence of HAART. The effect of antiretroviral (ARV) therapies on the incidence of serious non-AIDS events (SNAEs) has also been considered.

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