Cy umetofen is a novel benzoylacetonitile acaricide developed by Otsuka AgriTechno Co., Ltd. It has excellent e cacy against a variety of mites that attack fruits, nuts, vegetables, tea, and ornamentals. In addition, cy umetofen exhibited long persistence e cacy against mites. e new and unique chemistry of cy umetofen provides e ectiveness against mites that have developed resistance to existing acaricides. Extensive studies have shown that cy umetofen inhibits the mitochondrial electron-transport function of complex II, which is a novel target for the mode of action among pesticides. ese ndings suggest that cy umetofen could be an ideal component for integrated pest management (IPM) programs and resistant management programs because it is signi cantly safe for non-target organisms such as natural enemies and bene cial arthropods, and for the environment.

: A series of novel 6-(1,2,4-triazol-4-yl) chromone and -1-thiochromone (benzo [b]thiazin-4-one) derivatives was obtained by cyclisation via thiosemicarbazides which were prepared by reaction of hydrazines and the corresponding isothiocyanates. Their fungicidal activity was evaluated against the rice blast fungus Pyricularia oryzae. Of this series, 2,5,8-trimethyl-6-(1-propyl-5-thioxo-3-triÑuoromethyl-1,2,4-triazol-4-yl) chromone, 6-(1-butyl-5-thioxo-3-triÑuoro-methyl-1,2,4-triazol-4-yl)-2,5,8-trimethylchromone, 6-(1-hexyl-3-methyl-5-thioxo-1,2,4-triazol-4-yl)-2,5,8-trimethylchromone and 6-(1-allyl-5-thioxo-3-triÑuoro-methyl-1,2,4-triazol-4-yl)-2,5,8-trimethylchromone were highly active (pEC 50 [ StructureÈactivity relationship studies using the capacity factor k@ as a 6É0). hydrophobicity index suggested that the log k@ optimum for 2,5,8-trimethylchromone and -1-thiochromone derivatives was around 1É0, equivalent to a log value of c. 4É4. 1998 SCI P ow ( Pestic. Sci., 52, 309È320 (1998)

A series of novel 6‐(1,2,4‐triazol‐4‐yl) chromone and ‐1‐thiochromone (benzo[b]thiazin‐4‐one) derivatives was obtained by cyclisation via thiosemicarbazides which were prepared by reaction of hydrazines and the corresponding isothiocyanates. Their fungicidal activity was evaluated against the rice blast fungus Pyricularia oryzae. Of this series, 2,5,8‐trimethyl‐6‐(1‐propyl‐5‐thioxo‐3‐trifluoromethyl‐1,2,4‐triazol‐4‐yl) chromone, 6‐(1‐butyl‐5‐thioxo‐3‐trifluoromethyl‐1,2,4‐triazol‐4‐yl)‐2,5,8‐trimethylchromone, 6‐(1‐hexyl‐3‐methyl‐5‐thioxo‐1,2,4‐triazol‐4‐yl)‐2,5,8‐trimethylchromone and 6‐(1‐allyl‐5‐thioxo‐3‐trifluoromethyl‐1,2,4‐triazol‐4‐yl)‐2,5,8‐trimethylchromone were highly active (pEC50>6·0). Structure–activity relationship studies using the capacity factor k′ as a hydrophobicity index suggested that the log k′ optimum for 2,5,8‐trimethyl‐chromone and ‐1‐thiochromone derivatives was around 1·0, equivalent to a log Pow value of c. 4·4. © 1998 SCI