Alveolar-arterial Oxygen Tension Differences are one of the oxygenations that can increase SARS-CoV-2 virus infection. Based on this, the researchers wanted to assess the relationship between the baseline AaDO2 gradient and spirometry tests in severe COVID-19 survivors. This research is an observational analytic study with a cross-sectional design. The analysis was carried out in bivariate and multivariate tests assisted by using SPSS 26. The subjects who participated in the study were 80 people. Subjects with AaDO2 values ​​> 39.4 mmHg 70% (n=56), median AaDO2 gradient was 60.45 (2.75 - 548.2 mmHg). The relationship between baseline AaDO2 analysis and spirometry results showed that it was associated with FVC and FEF25-75% results, respectively (PR) 18.6 (95% CI 3.978-87.401 p = <0.001) and (PR) 7.7 (95% CI 1.606-3.724 p = 0.011) and no significant with FEV1 and FEV1/FVC values. This study concludes a relationship between a high baseline AaDO2 gradient with FVC and FEF values ​​of 25-75% in severe adult COVID-19 survivors. There was no relationship between a high baseline AaDO2 gradient and FEV1 and FEV1/FVC values.

The post-COVID-19 syndrome can affect the patients' activities. The hyperinflammatory response resulting in permanent organ system damage or prolonged inflammation is thought to cause persistent symptoms. Inflammatory and coagulation markers C-reactive protein (CRP) and d-dimer may increase in acute phase of SARS-CoV-2 infection and associated with unexpected outcome. Therefore, the researcher wanted to assess the association of baseline CRP and d-dimer levels with the six-minute walk test (6MWT) in severe COVID-19 survivors. This is a cross-sectional, observational analytic study. A total 80 participants were included in this study. The proportion of subjects with poor results of 6MWT was 71.3%. Bivariate analysis of high baseline level of CRP and d-dimer, and age 65 years old on the 6MWT showed significant results, with prevalence ratio (PR) consecutively 1.8 (95% CI1.408-2.284;p= <0.001),1.4 (95% CI1.165-1.796;p=0.018) , and 1.5 (95% CI 1.287-1.831; p= 0.008). Based on multivariate analysis, only high baseline level of CRP was significant (PR = 1.8, 95% CI 1.051-3.136; p = 0.032). The proportion of severe COVID-19 survivors with poor 6MWT was high. There is a significant association between high baseline levels of CRP with a poor 6MWT in severe COVID-19 survivors.

Pendahuluan. Pasien COVID-19 dengan diabetes melitus (DM) tipe 2 memiliki morbiditas dan mortalitas yang tinggi. Penelitian ini bertujuan untuk mengidentifikasi hubungan antara DM tipe 2 dengan berbagai luaran pada pasien COVID-19 di Rumah Sakit Sanglah Denpasar, Bali.Metode. Sebuah penelitian observasional analitik dengan pendekatan cross-sectional dilakukan pada pasien COVID-19 dengan dan tanpa komorbid DM tipe 2. Data yang digunakan adalah data sekunder dari rekam medis pasien terkonfirmasi COVID-19 yang dirawat di RSUP Sanglah mulai tanggal 1 Agustus 2020 sampai dengan 28 Februari 2022 dengan menggunakan teknik total sampling.Hasil. Terdapat 1.056 pasien yang terlibat dalam penelitian ini. Pasien didominasi oleh kelompok laki-laki (n=571; 54,1%), dengan median usia 59 tahun. Sebagian besar pasien dikategorikan sebagai COVID-19 berat (n=641; 60,7%) dan sebanyak 275 pasien menderita DM tipe 2 (26,0%). Analisis bivariat menunjukkan hubungan yang signifikan pada DM tipe 2