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Although coupled liquid chromatographygas chromatography (LC‐GC) was first demonstrated ten years ago, only in the last few years has there been a sudden surge of interest in the technique. Approximately 70% of the total number of LC‐GC applications have been published in the last two years (1987–88) alone. This review categorizes LC‐GC publications into four main application areas: fossil fuels, foods, environmental samples, biologiical/pharmaceutical samples, and miscellaneous samples. Multidimensional separations carried out using other coupled‐column chromatographic techniques (such as supercritical fluid chromatography (SFC) with GC, and on‐line trace enrichment‐GC) have also been included in this review.

Abstract.A multidimensional system based on capillary supercritical fluid chromatography (SFC) was constructed that utilizes a simple flow-switching interface between two open-tubular 50-pm i.d. columns. A novel solvent-venting injection technique was incorporated in the system that enables single or multiple 0.5-pL volumes to be injected into an uncoated, yet deactivated, length of capillary precolumn without flooding of the analytical column. The effectiveness of multidimensional capillary SFC (SFCSFC) for complex mixtures is demonstrated by the analysis of polycyclic aromatic hydrocarbons (PAH) in a coal tar extract, the trace determination of a methylcarbamate pesticide and its metabolites in a bird extract, and a group-type separation of hydrocarbons in a high-boiling petroleum distillate. These examples show for the first time that capillary SFC-SFC is a complementary alternative to other multidimensional chromatographic methods involving liquid or gaseous mobile phases.