Introduction: Medicinal plants have become increasingly useful as a form of alternative therapy. Cnidoscolus aconitifolius is a medicinal plant applied in folklore remedies in the treatment and prevention of various diseases. Aim: The aim of this study is to assess the effects of Cnidoscolus aconitifolius on some hematological parameters of male Wistar rats. Methodology: A total of 15 male Wistar rats weighing between 100-250 g were randomly placed in groups. Group 1 served as control and received distilled water only; group 2 received 200 mg/kg and group 3 received 400 mg/kg of the hydromethanolic leaf extract of Cnidoscolus aconitifolius. Extract was administered once daily using oro-gastric cannula for 30 days. Blood samples were collected by direct cardiac puncture into appropriate sample tubes for estimation of hematological parameters including red blood cell count (RBC), packed cell volume (PCV), haemoglobin (Hb) concentration, white blood cell count (WBC) and platelet count. Results: Results showed a significant (P<0.05) increase in RBC, PCV, Hb and platelet count with the higher dose of 400 mg/kg body weight of the extract compared to control group. However, the WBC count was not significantly (P>0.05) altered. Conclusion: Oral administration of the leaf extract of Cnidoscolus aconitifolius increases red blood cell count, packed cell volume, hemoglobin level and platelet count at 400 mg/kg body weight.

Introduction:The potency of plants is largely due to the presence of phytochemicals contain in them. Plant-derived chemicals influence endocrine activities in animals and humans have received affluent attention due to their possible adverse effects or benefits, especially on sex hormones. Aim: This study is aimed at evaluating the effect of hydromethanolic leaf extract of Cnidoscolus aconitifolius on sex hormones in streptozotocin induced-diabetic wistar rats. Materials and Methods: Thirty (30) wistar rats with an average weight of 230 grams, were randomly assigned into five groups of 6 (six) animals each. Group 1: served as negative control (non-diabetic) and received normal animal chow and water ad libitum, group 2: served as positive control group and received 10 mg/kg bw of glibenclamide, groups 3, 4 and 5 served as Original Research Article