Breast lump is the common complaint of women in clinics, which includes the second leading cause of cancer deaths in women.Objective: The study was conducted to know the pattern of female breast diseases in our setup at Hyderabad / Jamshoro. Design: Adescriptive Study. Setting: Liaquat University of Medical and Health Sciences, Jamshoro. Material & Methods: Descriptive study Setting: Itwas conducted in the department of pathology, Liaquat University of Medical and Health Sciences, Jamshoro. Period: Ten years from January2001 to December 2010. Results: Total of 2693 breast biopsies and mastectomies specimen included in this study, of which 278(10.32%)fibrocystic changes, 507(18.83%) inflammatory, 983(36.5%) benign and 889(33.01%) malignant. Conclusions: Benign Breast disease;fibroadenoma was the most common lesion. Infiltrating ductal carcinomas were next frequent, which reached hospital at late stage of disease.