Objective: To determine the indication and complications of exchange transfusion (ET) performed for neonatal hyperbilirubinaemia. Methods: The medical records of infants < 28 days old who required exchange transfusion (ET) due to neonatal jaundice in Special Care Baby Unit (SCABU), BIRDEM hospital from January 2009 to April 2010 were retrospectively reviewed. Results: Exchange transfusion was performed in 30 neonates during the study period. Indications of exchange transfusion were ABO incompatibility (30.0%), Rh incompatibility (13.3%), septicaemia (6.6%) and in majority causes, were unidentified (50%). Most common complication were thrombocytopenia (33.3%) hyperkalaemia (20%), hypocalcaemia (16.7%) Conclusion: Indication of ET was unidentified in majority cases and among identified cases most common causes was ABO incompatibility. Adverse events were common after exchange transfusion.DOI: http://dx.doi.org/10.3329/bjch.v36i1.13029Bangladesh J Child Health 2012; Vol 36 (1): 16-19
Objective: To determine the efficacy of subcutaneous methotrexate in patients with juvenile idiopathic arthritis (JIA) who failed to improve with oral methotrexate according to American College of Rheumatology 30 (ACR 30) improvement criteria. Design: Interventional Study. Setting: Rheumatology follow up clinic, Department of paediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka, Bangladesh, during the period from July 2006 to December 2008 . Methods: Twenty five patients who failed to improve with oral methotrexate were switched to subcutaneous methotrexate. Dose of methotrexate were same in both oral and subcutaneous route, at a dose of 10 mg/m2/week as a single dose. Results: According to ACR 30 criteria 76% patients improved after switching over to subcutaneous route. Among the core set variables active arthritis had the highest percentage of improvement and laboratory criteria (ESR) showed lowest improvement. Conclusion: From this study it may be concluded that subcutaneous methotrexate could be effective in patients with JIA who failed to improve with oral methotrexate. DOI: http://dx.doi.org/10.3329/bjch.v35i1.10368 BJCH 2011; 35(1): 16-19
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