Most techniques measuring corneal biomechanics in vivo are biased by side factors. We demonstrate the ability of optical coherence tomographic (OCT) vibrography to determine corneal material parameters, while reducing current prevalent restrictions of other techniques (such as intraocular pressure (IOP) and thickness dependency). Modal analysis was performed in a finite-element (FE) model to study the oscillation response in isolated thin corneal flaps/eye globes and to analyse the dependency of the frequency response function on: corneal elasticity, viscoelasticity, geometry (thickness and curvature), IOP and density. The model was verified experimentally in flaps from three bovine corneas and in two enucleated porcine eyes using sound excitation (100–110 dB) together with a phase-sensitive OCT to measure the frequency response function (range 50–510 Hz). Simulations showed that corneal vibration in flaps is sensitive to both, geometrical and biomechanical parameters, whereas in whole globes it is primarily sensitive to corneal biomechanical parameters only. Calculations based on the natural frequency shift revealed that flaps of the posterior cornea were 0.8 times less stiff than flaps from the anterior cornea and cross-linked corneas were 1.6 times stiffer than virgin corneas. Sensitivity analysis showed that natural vibration frequencies of whole globes were nearly independent from corneal thickness and IOP within the physiological range. OCT vibrography is a promising non-invasive technique to measure corneal elasticity without biases from corneal thickness and IOP.
The performance of an arrayed-waveguide grating (AWG) as an integrated spectrometer in spectral-domain optical low-coherence reflectometry (SD-OLCR) is significantly improved. By removing the output waveguides of the AWG, the depth range is enhanced from 1 to 3.3 mm at 800 nm and 4.6 mm at 1300 nm. Periodic signal fading, that was previously observed in the sensitivity roll-off curve in depth ranging measurements, is shown to be evoked by beat-frequency generation between the two polarizations of partially polarized signal light in a birefringent AWG. By carefully controlling the polarization state-of-light, the signal fading is eliminated. As a permanent solution to this problem, a polarization-independent AWG is demonstrated, which can reduce the size and cost of OCLR and optical coherence tomography systems further by eliminating the components for polarization control.
Optical properties of multilayer InAs quantum dot waveguides, grown by molecular beam epitaxy, have been studied under applied electric field. Fabry-Perot measurements at 1515 nm on InAs/GaAs quantum dot structures yield a significantly enhanced linear electro-optic efficiency compared to bulk GaAs. Electro-absorption measurements at 1300 nm showed increased absorption with applied field accompanied with red shift of the spectra. Spectral shifts of up to 21% under 18 Volt bias was observed at 1320 nm. Krestnikov, A. R. Kovsh M. Fischer, and J. Koeth, "Enhanced In(Ga)As/GaAs quantum dot based electrooptic modulation at 1.55 µ m," Appl. Phys. Lett. 91, 91118 (2007).
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