This research aims to develop an interactive E-Book based on animation for Vocational High School students. The subjects in this study were students of class X Light Vehicle Engineering SMK YP 17-1 Madiun. This type of research is development research adopted from the 4D development model and carried out at the third stage: define, design, and develop. The instruments used in this study include media validation sheets, response questionnaires and learning achievement tests. Based on media trials in the field, the following results were obtained: 1) The developed media was very valid (good) with an average result of a media validation questionnaire by experts at 97.92%. 2) Learning Media developed is very practical, by getting a very good response where an average questionnaire of 92.12% gives a positive response, 3) Interactive E-Book media developed are quite effective, where the completeness of student learning outcomes reaches 87.19%. From these results, it shows that the animated animated interactive E-Book media developed is very feasible to be used in supporting learning activities in the classroom.