It was demonstrated that medical students with vagotonia and sympathicotonia had a mild strain of their regulation mechanisms. The considerable signs of autonomic regulation inefficiency were found out in conditions of physical exercising. The adaptation of individuals with vagotonia to the physical loading was going mainly due to the excessive elevation of heart rate along with the increase in diastolic blood pressure. In contrast, abnormal elevation of pulse pressure after physical loading was observed in young people with sympathicotonia, which is concerned as a negative prognosis and also a predictor of arterial hypertension. Some physiological aspects of the recovery period confirmed the insufficiency of autonomic regulation as well as discoordination of the reciprocal departments of autonomic nervous system in examined persons. The unfavorable range of increase in hemodynamic parameters after physical loading was to pioneer. The following ranges of cardiovascular indexes indicated the mild level of maladaptation: in individuals with vagotonia – Mean Arterial Pressure by 6-30%, heart rate by 80-120%, endurance coefficient – 5-27%, and Robinson’s index – 121–200%; in persons with sympathicotonia – endurance coefficient – 5-27%, and Pulse Pressure – 75-105%. These changes have to be corrected in advance for the prophylactics of specific and nonspecific complications of visceral systems functioning. The economical effectiveness of this research is accomplished by the reduction of financial expenses because of prophylactics and/or diagnosis of autonomic deregulation development

The aim: Development of practical recommendations to further improve students' adaptation to a multicultural university environment as a factor in ensuring their health. Materials and methods: The publication is based on the results of a comprehensive multi-purpose randomized epidemiological study using a standardized questionnaire. Questionnaire results (n = 355) were tested for paired correlations of all considered factors. Results: 93,8 % of respondents positively assessed their overall health with a mode of 3 (satisfactory health). In general, students' health was not particularly sensitive to the effects of temporal and natural factors. Recommendations have been developed to improve students' adaptation to the university's multinational environment, including by preventing stressful situations. It is important that students are sufficiently informed, financially secure, and mentally prepared for student life. Conclusions: The key to safeguarding students' health is developing their skills in adapting to a multinational university environment.

Relevance. Fatigue, both intellectual and physical, reduces the efficiency of daily activities and quality of life, in addition, fatigue is one of the factors contributing to the development of various pathological conditions, such as cardiovascular disease and others. Therefore, it is important to understand the mechanisms underlying the development of fatigue, which will improve prevention and development. Objective: to analyze the physiological and biochemical mechanisms underlying the development of fatigue. Methods. Analysis of scientific publications of the international scientific database PubMed by keywords. The following research methods were used in writing the paper: systematization of material, analysis and generalization. Results. In this article we discussed the physiological and biochemical mechanisms of fatigue. The correlation between fatigue and the general mental condition, physiological, biochemical processes, activity of neurotransmitters, intellectual and physical activity, food has been defined. The central and peripheral mechanisms of fatigue were considered. Central fatigue is divided into spinal and supraspinal and involves the neuromuscular junction. Peripheral fatigue occurs at the level of the muscles and mainly involves muscle bioenergetics or an excitation-contraction coupling. Currently fatigue is considered as a general reaction to stress that lasts for a period of time, taken in an account the cumulative effects of days, weeks or months, and the effects of sleep disorders are also very important, because the effects of fatigue are closely linked to sleep deprivation. Therefore, the time required for recovery depends on the severity of fatigue. There are currently many research methods, such as electromyography, transcranial magnetic stimulation, magnetic resonance imaging, and spectroscopy, which are useful in undestending the physiological correlates of fatigue. In turn, psychological, behavioral or physical triggers can have a beneficial effect against the development of acute fatigue and improve performance, as well as provide a better understanding of the function of neurotransmitters, physiological and biochemical processes important in the development of body fatigue in general.