Background: Streptozotocin (STZ)-induced free radical oxidant activity resulted in muscle wasting due to protein carbonyl (PC), glucose transporter-4 (Glut-4), and interleukin-6 (IL-6) protein alteration. Antioxidant ingredient in the golden sea cucumber extract was found in promising level to inhibit free radical activity. Aim: This study was aimed to investigate the effect of golden sea cucumber extract on PC, IL-6, and Glut-4 level of STZ-induced diabetes mouse. Materials and Methods: This study was performed using mice, which were grouped into non-diabetes, diabetes, and diabetes-treated extract groups. The golden sea cucumber was extracted using 70% ethanol, which was administered by oral gavage twice a day for 5 consecutive days. Results: The extract reduced PC level and improved muscle Glut-4 and IL-6 protein level of diabetic mouse. Conclusion: The extract of golden sea cucumber revived muscle Glut-4 and IL-6 protein level in protection against muscle wasting.

Aim: Antioxidants, such as vitamin C and vitamin E, is widely used as supplements. The aim of this study is to analyze the profile of blood glucose, serum insulin, and HOMA in active teenagers after vitamin C and vitamin E supplementation. Methods: Subjects (14-16 y.o) consisted of 12 boys and 5 girls, divided into 3 groups: control (4 boys, 2 girls), 'moderate dose' of vitamin C and vitamin E combination group (5 boys, 1 girls), and 'high dose' of vitamin C and vitamin E combination group (3 boys, 2 girls). The treatment was given for 5 days. Vitamin C and vitamin E for 'moderate dose' was 500mg; 200IU, and for 'high dose' was 1000mg; 400IU. Fasting Blood Glucose (FGB) and 1 hour BG (1hr_BG), fasting serum insulin (FSI) and 1 hour SI (1hr_SI) was collected after treatment. We also calculated the HOMA-IR and HOMA-β. Result: There was no significant difference on FBG, 1hr_BG, FSI, 1hr_SI, HOMA-IR, and HOMA-β (p≥ 0.05). However, mean FBG and 1hr_BG tended to be higher on the treatment groups. The control group had the lowest HOMA-IR and the highest HOMA-β. Conclusions:We suggest that the supplementation of vitamin C and vitamin E in active teenagers is not essential on glucose homeostasis.

Human life quality is related to the density of daily physical activity. Human diseases are related to how many steps to take within a day. The level of human physical activity can be measured using the IPAQ scoring protocol, created by WHO in 1988. The relationship between IPAQ score and health problems show to be correlated. Nevertheless, the relationship between the level of physical activity using the IPAQ score instrument and resting heart rate is not known yet. This researcher conducted this study to determine the relationship between physical activity level using the IPAQ scoring protocol and rest heart rate. This study is an observative analytic with a cross-sectional study design using a simple random sampling technique. This study was conducted in Surabaya from November 2019 until March 2020 using primary data in the form of the IPAQ scoring method and resting heart rate examination using the Polar Heart Rate tool, which is then processed using IBM SPSS Statistics 22. The IPAQ score and resting heart rate measurement results using polar heart rate tools showed that the most college student has a high degree of physical activity level (72%) and a normal level of resting heart rate (90%). When measured with the Pearson correlation test, the correlation of those two components has a negative and weak correlation (r= -0,337, p<0,05). Overall, the correlation of physical activity level and resting heart rate are inverted and weak. For further research can be done to assess other things like one’s external stressors and lifestyle.

Introduction: Diarrhea is a significant health problem, especially in countries with low income. In many cases, diarrhea even can cause death. Treatment for diarrhea has been done both pharmacologically (including the usage of herbal remedies) and non-pharmacologically. Decoction of the sapodilla’s leaves is often used to treat diarrhea, but no studies directly demonstrates the effects of sapodilla’s leaves’ decoction towards living creatures. The purpose of this study was to determine the effect of sapodilla leaves’ (Achras zapota) infusum towards diarrheal activity of mice (Mus musculus) which can be seen through the onset and frequency of diarrhea, and the consistency and quantity / weight of feces.Methods: 30 mice were divided into five groups. Negative controls (group I) were administered with oleum Ricini, positive controls (group II) were administered with oleum Ricini and Loperamide HCl after half-an hour, and group III, IV, and V, were administered with oleum Ricini and sapodilla leaves’ (Achras zapota) infusum ( with the concentration of 5 g %, 10 g %, and 20 g %) after half-an hour. Then, those mice were observed for 3 hours for their diarrheal activity (diarrheal onset, frequency, fecal consistency, and fecal weights).Results: Analysis by Kruskal-Wallis method showed significant differences of diarrheal activities among the five groups (p = 0.023). Whilst, analysis by Mann-Whitney method showed significant differences between group I and II (p = 0.04), group I and III (p = 0.012), and group I and IV (p = 0.006).Conclusions: Based on the result showed sapodilla leaves’ (Achras zapota) infusum could reduce diarrheal activity of mice (Mus musculus).

Background: Skin aging is a physiological process that involves changes in skin cells and tissues due to abnormal mechanisms and decreased tissue function caused by both intrinsic and extrinsic factors. Skin aging has different clinical manifestations in each individual, which were classified using Glogau's photoaging classification. Purpose: The objective of this descriptive observational study is to evaluate the profile of skin aging patients at Dr. Soetomo General Hospital Surabaya from January – December 2019. Methods: This study utilized a total sampling technique from data obtained from the patients' medical records, which included age, gender, occupation, anamnesis, physical examination, diagnosis, and treatment received by patients. This research has been reviewed by the Ethics Committee at Dr. Soetomo General Hospital Surabaya (0438/KEPK/XII/2021). Result: Based on data obtained from medical records, 415 samples of skin aging patients were collected. The highest number of cases occurred among patients aged 45 - < 60 years. Most patients were female, and the majority of patients’ occupations were private employees. History taking findings include the most common complaint, namely dull skin, with the most precipitating factors discovered in patients, namely exposure to sunlight and pollution. Wrinkles were the most common physical examination finding in patients, with Glogau's photoaging III being the most common diagnosis. Most patients were treated with photoprotection in the form of sunscreen. Conclusion: With the increase of public awareness about appearance, as well as human health and quality of life, skin aging is receiving adequate attention nowadays, with sun exposure being the most common precipitating factor.