Background: Preferentially expressed antigen in melanoma (PRAME) is a cancer testis antigen (CTA) identified in 1997 through analysis of the specificity of tumor-reactive T-cell clones derived from a patient with metastatic cutaneous melanoma. Although at first it seemed even more specific, various studies have shown that PRAME can also be expressed in the context of atypical lesions that do not correspond solely to the definition of malignant melanoma. Methods: A systematic review of English articles was conducted following the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines. Results: 126 records were identified in the literature search, of which 9 were duplicates. After screening for eligibility and inclusion criteria, 53 publications were included. Conclusions: The advent of a new marker such as PRAME is surely a step forward not only in the diagnostic approach, but also in the immunotherapeutic approach to MM. However, various studies have shown that PRAME can also be expressed in the context of atypical lesions apart from MM and, for this reason, the diagnostic sensitivity and specificity (hence accuracy) are clearly lower. Further studies with larger case series will be necessary to understand better what possibilities are offered in terms of diagnostic reliability by PRAME.

The SARS-CoV-2 pandemic has affected health systems across the globe, making the use of vaccines more urgent and topical than ever. Since the first months after the introduction of vaccinations, several reactions, both local and systemic, have been reported although they were mostly very mild and only rarely harbingers of more serious complications. We present a case of multiple flat warts onset over the cheeks in a patient after the second dose of mRNA BioNTech-Pfizer BNT162b2 vaccine, and we discuss the possible temporal association between the two events, also considering the patient’s antibody status.

Background: balloon cell melanoma represents less than 1% of all histological forms of malignant melanoma and represents a diagnostic challenge for the dermatopathologist. Methods: in this paper we present our cases of BCM found in our daily practice from 1 January 2008 to 31 December 2021, and we conduct a review of the literature relating to this entity in the period from the first description, 1970, to early 2022. Results: four cases of melanoma balloon cell have been extrapolated from our electronic database, while in the review of the literature we have identified 115 cases of patients with primary and/or metastatic BCM. Conclusions: we believe that future studies with numerous case series are essential not only to increase the knowledge of the pathophysiology of this neoplasm but also to correctly evaluate the response of BCM patients to new oncological therapies.

Laser therapy has become one of the gold standards of treatment in routine dentistry. In the 1970s, CO2 lasers were the first lasers to be used in oral surgery on soft tissues. Subsequently, other lasers (Diode, Nd YAG, Er: YAG, Argon and Erbium) have also been used in periodontics, implantology, orthodontics and restorative dentistry, as well as for hard tissues, such as bone, enamel and dentin. The purpose of this systematic review is to analyze both the therapeutic properties and adverse effects of laser use in dentistry, related to a non-targeted choice of medical device based on clinical need as well as an inadequate learning curve. A systematic review was performed following the PRISMA guidelines using Pubmed, Scopus and Web of Science. The use of lasers requires a specific learning curve modifying the standard surgical approach. The use of lasers provides multiple therapeutic benefits but can lead to some failures in dental treatments. In restorative dentistry, it has been found that lasers can cause cracks that can lead to fractures and/or affect the composite restoration. In periodontal treatments, the use of lasers can produce thermal damage to pulp tissue. In surgical treatments, the use of a laser caused bleeding, post-operative pain and a burning sensation. The failure of tissue cooling during laser beam emission could produce the necrosis of hard and soft tissues.

Various adverse reactions to SARS-CoV-2 vaccines have been described since the first months of the vaccination campaign. In addition to more frequent reactions, rare reactions, such as sarcoidosis-like, rashes have been reported. We present a case of a 23-year-old woman with a rash on the chin and peribuccal region, which developed approximately 3 weeks after the administration of the second dose of the Moderna mRNA-1273 vaccine. We briefly discuss other reports in the literature.