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2 patients with long-standing and wide-spread pityriasis lichenoides chronica were treated with orally administered 8-methoxypsoralen and UVA irradiation (PUVA therapy). After 15–21 PUVA treatments the patients were completely cleared. 3 and 4 weeks after the initial PUVA treatment, phase recurrences occurred in both patients. In 1 patient the lesions appeared clinically and histologically as pityriasis lichenoides et varioliformis acuta.

A 20-year-old male patient was treated topically with 8-methoxypsoralen and long-wave ultraviolet light (UV-A) for alopecia areata. He developed contact allergy to 8-methoxypsoralen after the sixth treatment (day 17), which was verified by patch testing and histopathology.

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