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(14 (6-29) hours) than in patients with depression (49 (35-71) hours) (p<0.001), and controls (42 (10-68) hours) (p<0-001). In patients with anxiety, orocaecal transit time was shorter (60 (10-70) minutes) than in patients with depression (110 (60-180) minutes) (p<0.01), and shorter than in controls (75 (50-140)) minutes (p<0.05). The prolongation oftransit times in depression compared with controls was not significant. However, WGTT correlated with both the Beck Depression Inventory score (r=0.59, p<0.01) and the depression score of the Hospital Anxiety and Depression scale (r=0.66, p<0.001). Conclusions-These objective measurements of intestinal transit in affective disorders are consistent with clinical impressions that anxiety is associated with increased bowel frequency, and depressed patients tend to be constipated; mood has an effect on intestinal motor function.

The cognitive model of depression assigns a central role to negatively biased information processing in the pathogenesis of the emotional disorder. The relationship between depression and irritable bowel syndrome (IBS) was explored from a cognitive perspective. A word recognition memory task was constructed: subjects had to memorise and subsequently recognise a set of emotionally loaded stimulus words with either positive, neutral, or negative connotations.

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