No bacteria were observed in an epizootic of lethal pneumonia in guineapigs. Necrotic bronchitis and bronchiolitis with basophilic intranuclear inclusion bodies in bronchial epithelial cells were characteristic. Although adenovirus infection of guineapigs has not previously been reported, histological findings paralleled those found in adenovirus infections of other animals including man. Virus particles found by electron-microscopical examination of the lung tissue closely resembled adenoviruses. The disease seemed to have a low contagiousness, a low morbidity (about 0·7%), but an acute course and a high mortality (100%).

After concentration and purification steps involving ultracentrifugation, density gradient centrifugation in potassium tartrate and rate zonal centrifugation in saccharose the virus of bovine virus diarrhea-mucosal disease of cattle (strain Oregon C24 V) was studied electron microscopically. The virion consists of an envelope without projections and a nucleocapsid probably displaying a cubical symmetry. The particle has a diameter of 57 • 7 m~z the core accounting for 24 q-4m~z.The morphological relationship to other viruses is discussed. ZusammenfassungNach der Konzentration durch Ultrazentrifugierung und nach Reinigungsschritten durch Dichtezentrifugierung in Kaliumtartrat und Zonenzentrifugierung in Saccharose wurde das Virus der bovinen Virusdiarrhoe-Mucosal Disease (Stamm Oregon C24 V) elektronenoptisch dargestellt. Das Virion besteht aus einer Hfille ohne Projektionen und einem wahrscheinlich kubisch-symmetrischen Nukleokapsid. Der Durchmesser des Virion betr/~gt 57 • 7 m~z, der des Innen-kSrpers 24 =k 4 m~z.Die morphologische Verwandtschaft mit anderen Viren wird diskutiert.

No abstract

Post-mating non-infectious hydrometra and hydrovagina of unknown aetiology, leading to a scrotum-like swelling of the perineum, was observed during an experiment on BALB/c: Bom mice. There was a closure of the vulva with accumulation of secretions of uterine glands under high pressure in both uterus and vagina. The mice were otherwise clinically healthy, gained body weight normally, but were incapable of breeding. The morbidity was approximately 1% and the disease could not be transmitted to other females.