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Objective: To synthesize inclusion complexes of oral antidiabetic drugs, i.e., Glipizide (GP) and Gliclazide (Glc) with a-cyclodextrin (α-CD) and varying the pH which will enhance the solubility and thereby oral bioavailability of the drugs.Methods: Liquid inclusion complexes were prepared and characterized by ultraviolet-visible (UV-VIS) spectroscopic studies, and fluorescent studies solid inclusion complexes of GP and Glc with α-CD were prepared by co-evaporation method and characterized by differential scanning calorimetric studies (DSC) and 1 H nuclear magnetic resonance spectroscopic studies ( 1 H NMR). Results:The inclusion complexes of both GP and Glc with α-CD showed high binding constant values for pH 2 from the UV-VIS spectroscopy studies and fluorescent studies. DSC and 1 H NMR spectroscopic studies confirmed the inclusion of GP and Glc inside the α-CD cavity. Conclusion:Formed with more stable inclusion complexes, with α-CD are GP and Glc at pH 2, along with pH modulation could be a suitable strategy to enhance the solubility and oral bioavailability of both the drugs.

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