BackgroundThe electronic nose (e-nose) detects volatile organic compounds (VOCs) in exhaled air. We hypothesized that the exhaled VOCs print is different in stable vs. exacerbated patients with chronic obstructive pulmonary disease (COPD), particularly if the latter is associated with airway bacterial infection, and that the e-nose can distinguish them.MethodsSmell-prints of the bacteria most commonly involved in exacerbations of COPD (ECOPD) were identified in vitro. Subsequently, we tested our hypothesis in 93 patients with ECOPD, 19 of them with pneumonia, 50 with stable COPD and 30 healthy controls in a cross-sectional case-controlled study. Secondly, ECOPD patients were re-studied after 2 months if clinically stable. Exhaled air was collected within a Tedlar bag and processed by a Cynarose 320 e-nose. Breath-prints were analyzed by Linear Discriminant Analysis (LDA) with “One Out” technique and Sensor logic Relations (SLR). Sputum samples were collected for culture.ResultsECOPD with evidence of infection were significantly distinguishable from non-infected ECOPD (p = 0.018), with better accuracy when ECOPD was associated to pneumonia. The same patients with ECOPD were significantly distinguishable from stable COPD during follow-up (p = 0.018), unless the patient was colonized. Additionally, breath-prints from COPD patients were significantly distinguished from healthy controls. Various bacteria species were identified in culture but the e-nose was unable to identify accurately the bacteria smell-print in infected patients.ConclusionE-nose can identify ECOPD, especially if associated with airway bacterial infection or pneumonia.

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The cell static noise margin (SNM) is widely used as a stability criterion for static random-access memory cells design. This parameter is typically determined through electrical simulations since direct experimental characterization of SNM is not achievable.In this work, we present a methodology that provides an indirect measurement of the SNM on a per-cell basis for six-transistor SRAMs. It is based on combining an Adaptive Neuro-Fuzzy Inference System (ANFIS) with circuit-level cell experimentally measurable parameters as input variables to the tool. We show that it is possible to obtain the SNM for individual memory cells using the same experimental setup and data than that required for shmoo plot measurements. Results confirm that the SNM can be experimentally estimated with a relative error compared with electrical simulations that is below 0.5%.