We demonstrate a carrier-envelope phase (CEP) stabilized high temporal contrast generator at 1053 nm for the first time. The device relies on a collinear optical parametric amplifier (OPA) followed by a frequency-doubling crystal. It is driven by a femtosecond laser source centered at 800 nm and finally generates CEP passively stabilized pulses with an energy of 130 µJ and a FWHM for the spectrum of 40 nm with 46 fs pulse duration at 1053 nm. The temporal contrast reaches >10 11 at a few picoseconds before the main pulse.

Early and differential diagnosis of Alzheimer's disease (AD) has puzzled many clinicians. In this work, laser Raman spectroscopy (LRS) was developed to diagnose AD from platelet samples from AD transgenic mice and non-transgenic controls of different ages. An adaptive Gaussian process (GP) classification algorithm was used to re-establish the classification models of early AD, advanced AD and the control group with just two features and the capacity for noise reduction. Compared with the previous multilayer perceptron network method, the GP showed much better classification performance with the same feature set. Besides, spectra of platelets isolated from AD and Parkinson's disease (PD) mice were also discriminated. Spectral data from 4 month AD (n = 39) and 12 month AD (n = 104) platelets, as well as control data (n = 135), were collected. Prospective application of the algorithm to the data set resulted in a sensitivity of 80%, a specificity of about 100% and a Matthews correlation coefficient of 0.81. Samples from PD (n = 120) platelets were also collected for differentiation from 12 month AD. The results suggest that platelet LRS detection analysis with the GP appears to be an easier and more accurate method than current ones for early and differential diagnosis of AD.