No abstract

Significantly fewer bacteremic episodes with Gram-negative organisms occurred in the glutamine-supplemented patients. Glutamine supplementation improved measures of nutrition and decreased measures of overall inflammation. In addition, a trend toward lower mortality rate, decreased overall bacteremia incidence, and antibiotic usage in the glutamine group was observed. Glutamine's beneficial effects may be a result of improved gut integrity or immune function, but the precise mechanism of glutamine's protection is unknown.

These observations demonstrate that remote in vivo administration of GLN before cardiac I/R injury can improve post-I/R cardiac function. This effect may be mediated via improved myocardial metabolism and enhanced reduced glutathione content.

No abstract

To investigate the effects of venetoclax on the anti-tumor activity of anti-PD-1/PD-L1 treatment, we performed tumor efficacy studies in immunocompetent C57BL/6 mice bearing MC38 tumors. Analysis from eight independent studies indicated that, as expected, anti-PD-1 led to significant tumor growth inhibition compared to isotype control (p-value = 0.0001) and this was, unexpectedly, further enhanced by co-treatment with venetoclax (venetoclax / anti-PD-1 cotreatment vs. anti-PD-1 alone, p-value = 0.005) (Fig. 1A, Supplementary Fig. 1A-I). Venetoclax also increased tumor growth inhibition when combined with anti-PD-L1 (Supplementary Fig. 2).Research.