Metal complexes of malonie acid (metal Mn(II), Co(II), Ni(II), Cu(II), Zn(II), Ag(I)) were prepared and only the Ag(I) complex inhibited the growth of Candida albicans. Malonate complexes incorporating the chelating 1,10-phenanthroline (1,10-phen) ligand showed a range of activities: good (Mn(II), Cu(lI), Ag(I)); moderate (Zn(II)); poor (Co(II), Ni(II)). Metal-free 1,10-phen and Ag(CH3CO2) were also highly active. The metal-free non-chelating ligands 1,7-phenanthroline and 4,7-phenanthroline were inactive and the Cu(II), Mn(II) and Zn(II) complexs of 1,7-phen displayed only marginal activity. Whereas the Cu(II) malonate/1,10-phen complex induces significant cellular oxidative stress the Zn(II) analogue does not.
SUMMARY
Clinical and biochemical observations on eleven cases of post‐anaesthetic forelimb lameness were compared with similar studies on horses anaesthetised in lateral recumbency making an uneventful recovery. It is suggested that the condition resulted from muscular ischaemia during the recumbent phase.
RÉSUMÉ
Les observations cliniques et biochimiques sur 11 cas de boiteries post anesthésiques sont comparées à celles de même nature faites sur des chevaux ayant été anesthésiés sans suite aucune.
Il semblerait que les boiteries soient, dans ces cas mentionnés, le résultat d'une ischémie musculaire durant la phase de decubitus.
ZUSAMMENFASSUNG
Klinische und biochemische Beobachtungen an einem Material von elf post‐narkotischen Lahmheiten der Vordergliedmassen werden verglichen mit ähnlichen Untersuchungen an Pferden, die in Seitenlage narkotisiert wurden und sich normal erholten. Es wird vermutet, dass der Zustand auf eine Muskelischaemie während des Liegens zurückzuführen sei.
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