Availability of basic tools for engineering molecular systems with precisely defined properties is crucial toward progress in development of new responsive materials. Among such materials are systems capable of generating an ultrasensitive response (i.e., large relative changes in output in response to small changes in input). Herein, we focus on a rational design of DNA quadruplex based structures as ultrasensitive response elements. In particular, we demonstrate how addition of allosteric guiding elements can be engineered into H(+)-responsive i-motif structure to yield maximized response sensitivity.

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This chapter starts by describing the nature of the evidence of the language and style of the fragmentary republican historians. It also refers to a number of usages which are absent, or virtually absent, from Cicero and Caesar: some of these are found in Latin – primarily, of course, in poetry – of a time before that of the historian concerned, while others occur for the first time in the author in question. The chapter specifically discusses archaisms and neologisms. It also reports the successors of Cato I. The verbatim fragments of L. Cassius Hemina, Q. Fabius Maximus Servilianus, L. Calpurnius Piso, C. Fannius and Cn. Gellius, L. Coelius Antipater, Sempronius Asellio, Q. Claudius Quadrigarius, Valerius Antias, L. Cornelius Sisenna, and C. Licinius Macer are then explored. The surviving longer fragments, with a few exceptions, exhibit a simple sentence structure, with a minimum of subordination.

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