No abstract

In the present work, the development of experimental leishmaniasis was examined in sensitized BALB/c mice that were chronically fed with antigen. After an oral challenge with egg white solution, the ovalbumin (Ova)-sensitized mice showed an increase in serum anti-Ova IgE and IgG1 antibodies. Lesions induced by Leishmania major infection were reduced by the ingestion of Ova in sensitized mice, as assessed by reduced footpad growth, lower parasite loads and improved pathological outcome compared to sham sensitized mice. Moreover, such findings were connected to a shift to a Th1 response involving higher IFN-gamma production and serum levels of IgG2a anti-Leishmania antigens. The data appear to corroborate the suggestion that chronic ingestion of an antigen by sensitized mice modulates the immunological system through a shift in cytokine release, exhibiting a healing response and resistance to L. major infection.

No abstract

A pandemia do COVID-19, deflagrada no início de 2020, foi acompanhada por rápida disseminação, taxas de mortalidade sem barreiras sociais e uma corrida científica sem precedentes.Neste cenário mundial o Brasil tem lugar de destaque, pois é o 11º país que mais produziu artigos sobre o assunto. Este e-book tenho o objetivo de expor as pesquisas epidemiológicas, revisões científicas, estudos experimentais pré-clínicos, observacionais e clínicos sobre o assunto COVID-19 -O VÍRUS QUE MOVIMENTOU A CIÊNCIA.Esperamos que tenha uma leitura agradável e possa desfrutar ao máximo o conhecimento transmitido por nossos autores.

No abstract