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to evaluate and compare the pharmacokinetic (pK) characteristics of a newly developed oral osmotically controlled drug delivery system of Eperisone 150 mg tablets with Eperisone immediate release (iR) marketed tablet brand as a reference formulation. it was a single dose, two treatment, two sequence, randomized, crossover study, involving 12 healthy human subjects. A modified, sensitive Lc-eSi-MS/MS method was developed and validated as per fDA guidelines for estimation of eperisone in plasma using a simple extraction and quick protein precipitation method. non-compartmental pharmacokinetic model was used for pK analysis. Results were statistically compared using logarithmically transformed data, where p > 0.05 was considered as non-significant with 90% CI limit of 0.8-1.25. The bio-analytical method used for estimating drug plasma concentration was found to be simple, selective, linear, accurate and precise with 0.01 ng/ml as limit of detection. The comparative PK analysis revealed an insignificant difference in AUC 0-∞, AUC 0-t, V z /f, cl/f and t 1/2λz , whereas a significant difference in C max , t max and Mtts were found. the relative bioavailability of eperisone osmotic tablet was 109.7%. The osmotic controlled release drug formulation was found to release Eperisone for an extended period with less inter individual fluctuation in pharmacokinetic variables.

Objective:To see the frequency of incidental fatty liver on ultrasound and its association with diabetes mellitus and hypertension.Methods:A cross sectional study was conducted from January 2016 to June 2016 in the department of Surgery and Radiology at Hamdard University Hospital. Patients of both genders and all ages were selected by non purposive convenience sampling. Critically ill, trauma cases and all those patients who had a history of chronic liver disease, alcohol intake and expected pregnancy were excluded. Blood pressure and random blood sugar were recorded.Results:Six hundred patients were included in the study with mean age of 44.65±18.8 years. 240 patients (40%) had incidental finding of fatty liver on ultrasound. Out of 240 with fatty liver patients 117 were males (48.8%) and 123 were females (51.3%). Total 141 patients were diagnosed with hypertension, out of which 81(57.44%, p< 0.001) had fatty liver on ultrasound. Diabetes mellitus was diagnosed in 84 patients, in which 57 patients (67.8%, p<0.001) had fatty liver.Conclusion:Fatty liver is a frequently found incidental finding on ultrasound. There is a significant association of fatty liver with diabetes mellitus and hypertension.

This study aims to evaluate the effect of different spices (black pepper, cumin, clove, nigella, cardamom, and cinnamon) on the physicochemical characteristics and microbial quality, as well as antioxidant potential, of paneer during storage. Different types of spices were incorporated into the paneer at different levels (0.2 and 0.3%). In addition to paneer, the antioxidant potential of spices was also investigated. The results concerning total plate counts (TPC) or yeast and molds (Y & M) (log10 CFU/g) of all treatments were substantially (p < 0.05) increased during storage. Generally, all freshly prepared spicy paneer and control had higher sensory scores for all the sensory characteristics which declined during subsequent storage. All the paneer samples having 0.3% spices showed very slight variations (nonsignificant) in sensory score of all the attributes of their relative samples containing 0.2% spice. The incorporation of spices into the paneer matrix also showed promising results concerning all the above-mentioned attributes revealing antioxidant potential. There was significant (p < 0.05) effect of treatments and storage days on antioxidant potential of paneer. The freshly prepared control paneer (P0) showed the lowest total phenol (TP), total flavonoids (TF), 2, 2-diphenyl-1-picrylhydrazyl (DPPH), reducing power (RP), and total antioxidant capacity (TAC) values compared to all the spicy paneer (treatments). The freshly prepared control paneer (P0) showed the lowest antioxidant potential compared to all the spicy paneer (treatments). The maximum antioxidant potential was observed in the paneer having 0.3% clove (P6). All the spicy paneer showed increasing trend of all the attributes, showing antioxidant potential up to 6 days of storage, but afterwards, the activities were slightly decreased. It may be concluded that spicy paneer would be considered as a functional dairy product with enhanced sensory and antioxidant properties, and shelf stability.

Background: The rehabilitation of edentulous patients requires acrylic resin complete dentures to fulfil their functional and esthetic needs. Fractures of dentures are one of the commonest complaints around the world. Aim: To evaluate the frequency of acrylic complete denture fractures among edentulous patients and find out their association with certain variables. Methodology: A cross sectional observational study was carried out in Prosthodontic department of Lahore Medical and Dental College, Lahore from 26th March 2020 to 26th September 2021. A total of 58 completely edentulous patients reported with fractured acrylic dentures were selected. Patients were evaluated both intra and extra orally to find out the cause and site of fracture. Various parameters namely, denture age, fracture sites, gender were statistically evaluated to find out their relationship with denture fracture. Results: Results showed that male patients; 56.9% were presenting more with fractured dentures than female; 43.10%. In males the midline denture fractures were most commonly seen 45.5%, whereas in females’ fracture at premolar area was commonly observed 28.0% however no statistical dependance between fractured dentures sites and gender was found. Denture fractures were most prevalent in mandibular arch 50% as compared to maxillary 39.7%. Mid line fracture was the commonest site observed in both maxillary 30.4% and mandibular arches 31.0%. Insignificant association between fracture sites and dental arches was seen. Maximum denture fractures were recorded in first 2 years of denture fabrication 55.2%. The most frequent cause of denture fracture was accidental falling 34.5%. Conclusion: The frequency of complete denture fracture is more in mandible as compared to maxilla and the main reason is patients’ negligence. The study also showed midline fracture of dentures to be the most frequent site of denture fracture. Keywords: Acrylic dentures, Complete dentures, Edentulism, Edentulous, Prosthesis, Tooth loss,