Different types of DNA have been used to investigate binding interactions of Cu(TMpyP4), where TMpyP4 denotes the deprotonated form of mesotetrakis(4-(/V-methylpyridiniumyl))porphyrin. Physical methods employed include electronic absorption and circular dichroism as well as luminescence spectroscopy. Most of the studies have been carried out at µ = 0.2 M in a pH 7.8 Tris buffer at 25 °C. With DNA samples containing both guanine-cytosine and adenine-thymine base pairs, our results confirm that Cu(TMpyP4) can bind at external sites-most likely within one of the grooves of DNA-or by intercalation (

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