An Approach to Preparation of trans-DHQs via Ring-Opening of meso-N-Sulfonylaziridines. -The ring opening of aziridine derivative (I) is studied. Enantiomeric excess values up to 40% are obtained if the ring opening with Tms-CN is performed in the presence of chiral ligands. Aziridine (I) can be used as starting material for the synthesis of trans-octahydroquinoline (XIII). -(NOLSOEE, J.; RIEGERT, D.; MUELLER*, P.; TANNER, D.; Collect. Czech. Chem. Commun. 76 (2011) 7, 815-828, http://dx.doi.org/10.1135/cccc2011013 ; Dep. Org. Chem., Univ. Geneva, CH-1211 Geneva 4, Switz.; Eng.) -M. Bohle 43-143

Synthesis of 8-Halopurines by Reaction of Lithiated Purines withAppropriate Halogen Donors.-Lithiation of purine nucleosides such as (I) followed by trapping with hexachloroethane, dibromotetrachloroethane or cyanogen halides provides a facile and highly efficient route to corresponding 8-halopurines [cf. (II)]. -(NOLSOEE, J. M. J.; GUNDERSEN, L.-L.; RISE, F.; Synth. Commun. 28 (1998) 23, 4303-4315; Dep. Chem., Univ. Oslo, N-0315 Oslo, Norway; EN)

The acid‐mediated condensation of benzoylpyruvates (I) with aza‐heterocyclic amines (II), N‐amino heterocycles (IV) and (VI), C,N‐dinucleophiles (VIII), and anilines (X) furnishes the corresponding heterocyclic imprints in good yields.

Organic chemistry Z 0200 Benzoylpyruvates in Heterocyclic Chemistry -[synthesis of pyrazoles, pyridines, pyrimidines, pyrazines, oxazines; 61 refs.]. -(NOLSOEE, J. M. J.; WEIGELT*, D.; J. Heterocycl. Chem. 46 (2009) 1, 1-9; Dep. Med. Chem., CNS Res. Dev., Astra Arcus AB, S-151 85 Soedertaelje, Swed.; Eng.) -H. Haber 29-234

Synthesis -[51 refs. + subrefs.]. -(NOLSOEE, J. M. J.; AURSNES, M.; TUNGEN, J. E.; HANSEN*, T. V.; J. Org. Chem. 80 (2015) 11, 5377-5385, http://dx.doi.org/10.1021/acs.joc.5b00879 ; Dep. Pharm. Chem., Sch. Pharm., Univ. Oslo, N-0316 Oslo, Norway; Eng.) -Nuesgen 32-273