Aim of the study is to evaluate the expression of CK19, galectin-3, HBME-1, CD56,claudin-1andneutrophilgelatinase-associatedlipocalin(NGAL)inpapillarythyroidcarcinoma(PTC),includingclassic,follicularvariantandmicro-carcinoma.Peritumoralbenignthyroidtissueswereusedasacontrol(C). ImmunohistochemicalstainingwiththeEnVisiondetectionsystemwasperformedon 59formalin-fixed,paraffin-embeddedthyroidtissues,including43PTCand16C. CK19, galectin-3, HBME-1, claudin-1 and NGAL were positive in most PTC, butwerenegativeorshowedfocalweakstaininginC.CD56waspositiveinC,but ab sentinPTC.Forasingleanalyzedtumormarker,thesensitivityoftheabovesix thyroidtumormarkerswas100%,95.3%,86%,79.1%,90.7%,93%,respectively.Thespecificitywas56.25%,100%,100%,100%,100%,100%,respectively. Forthecombinationofthesixtumormarkers,thesensitivity,specificity,positive predictive value, negative predictive value and the diagnostic accuracy were all 100%,withco-expressionofatleastfourindices. InthediagnosisofPTC,combinedapplicationoftheabovetumormarkersisrecommended.ItcanbediagnosedasPTCclearlywhenthyroidlesionsarepositivefor atleastfouroftheabovetumormarkers[CD56(-)],andcanbeexcludedasPTC definitelywhenatleastfourtumormarkersarenegative[CD56(+)].

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Background: Helicobacter pylori (H. pylori) is increasingly associated with extra-digestive diseases. Infertility is a common condition, with an incidence of 10 to 15% of couples. Studies examining the association of H. pylori infection and infertility have reported conflicting results. This meta-analysis aimed to investigate the association between H. pylori infection and infertility. Methods: Studies of H. pylori infection and infertility were identified in PubMed, EMBASE, the Cochrane Library, and China National Knowledge Infrastructure. We performed a meta-analysis of all case-control studies. Results: Seven studies that analyzed the relationship between H. pylori infection and infertility, with a combined study population of 1,902 patients, were included in the meta-analysis (n = 626 for patients; n = 1,276 for controls). In the infertility group, 344 (54.9%) patients were H. pylori-positive, and 495 (38.8%) were H. pylori-positive in the control group. Our result suggested that H. pylori infection was associated significantly with infertility (OR = 1.45, 95% CI: 1.197-2.160; I 2 = 36.5%, Z = 3.15, p = 0.002). Begg's and Egger's funnel plot showed no publication bias (p = 0.807). Conclusions: Our meta-analysis identified a possible association between H. pylori infection and infertility.

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