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Magnetically driven drug delivery systems of superparamagnetic iron oxide nanoparticles have a considerable potential as candidates to overcome the present obstacles of drug delivery in anti-tumor therapy owing to its remote controllability by external magnetic fields and other unique properties. In this work, a biodegradable anionic copolymer with side carboxylic groups named methoxy-poly (ethylene glycol)-block-poly(α-carboxyl-ε-caprolactone) was synthesized to complex iron oxide magnetic nanoparticles and load paclitaxel (PTX) to form dual-stimuli responsive copolymer-magnetite superparamagnetic nanocomposites with an elastic core and carboxylic groups on the surface in a very easy way. The physiochemical properties of these nanocomposites were measured. High PTX loading content and high saturation magnetization were obtained. Being proved to be stable at a wide pH range and low cytotoxic in vitro, these nanocomposites presented faster PTX release in vitro at pH 6.5 than at pH 7.4 and obviously reduced burst release.

Based on the characteristics that ethylene glycol (EG) has strong solubility of inorganic salts and ethylene glycol and water are soluble, a new process was proposed where glycol was taken as a solvent for extraction to separate the salts in crude oil in order to achieve highly efficient removal of salt from crude oil. This paper investigates the main factors in the desalting process of glycol extraction, including the mixing intensity, mixing time, extraction temperature, sedimentation time, and other factors. The results showed that when mixing intensity was 8 kr/min, mixing time was 8 min, the extraction temperature was 110 °C, and the settling time was 180 min, the salt content of the first extraction was 7.14 mg NaCl/L, and the salt content of the secondary extraction is 2.61 mg NaCl/L. The total desalination rate is 94%. It was found that the full contact of ethylene glycol and crude oil could promote the desalting process by using microscopic analysis. Ethylene glycol extraction desalting technology provides a new method for a refining process economically.