The association between tumor EpsteinBarr virus (EBV) status and clinical outcome in Hodgkin lymphoma (HL) is controversial. This population-based study assessed the impact of EBV status on survival in age-stratified cohorts of adults with classic HL (cHL). Data from 437 cases were analyzed with a median follow-up of 93 months. Overall survival (OS) was significantly better for EBVnegative compared with EBV-positive patients (P < .001), with 5-year survival rates of 81% and 66%, respectively; diseasespecific survival (DSS) was also greater for EBV-negative patients (P ‫؍‬ .03). The impact of EBV status varied with age at diagnosis. In patients aged 16 to 34 years, EBV-associated cases had a survival advantage compared with EBV-negative cases, but differences were not statistically significant (P ‫؍‬ .21). Among patients 50 years or older, EBV positivity was associated with a significantly poorer outcome (P ‫؍‬ .

LOPP chemotherapy for T cell lymphoma is well tolerated with a low toxicity profile and an excellent overall response rate. This protocol showed minimal toxicity and comparable disease free interval and survival times for canine high grade T cell lymphoma treated with CHOP.

The low incidence of t(14;18) and favourable outcome encountered in ENFL in this study is similar to that previously found for primary cutaneous FL. These results support the concept of a subtype of FL lacking t(14;18) involving the major breakpoint cluster region, and with a propensity to arise at extranodal sites. Despite a high relapse rate, patients with ENFL are more likely to achieve complete remission and may ultimately have a more favourable long-term prognosis than those with equivalent nodal disease.

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Foreword This document was commissioned to provide UK veterinary surgeons with up-to-date information on Streptococcus equi infection and to provide practical recommendations for veterinary surgeons in the field. The participants were selected to provide representation from a range of expertise and viewpoints and included practitioners, academics and social scientists. The document and practical recommendations were developed using a modified non-anonymised two-round Delphi process, considering published and unpublished research relating to ‘strangles’ using online discussion. The expert group was convened by UK-Vet Equine and Redwings and an online meeting held on 20th January 2021 with sponsorship from MSD and support from World Horse Welfare. The sponsors did not participate in the meeting and had no influence over editorial content. Each of the panellists was provided with a sub-topic and presented a review of the evidence pertaining to that area prior to taking two rounds of questions relating to the evidence presented. Where research evidence was conflicting or absent, collective expert opinion, based on the experience of the group, was applied. The opinions expressed are the consensus of views expressed by the authors who all approved the final manuscript. Where it was not possible to reach consensus, different viewpoints are presented.