Background: There is growing concern about individuals reported to suffer repeat COVID-19 disease episodes, these in a small number of cases characterised as de novo infections with distinct sequences, indicative of insufficient protective immunity even in the short term. Methods: Observational case series and case-control studies reporting 33 cases of recurrent, symptomatic, qRT-PCR positive COVID-19. Recurrent disease was defined as symptomatic recurrence after symptom-free clinical recovery, with release from isolation > 14 days from the beginning of symptoms confirmed by qRT-PCR. The case control study-design compared this group of patients with a control group of 62 patients randomly selected from the same COVID-19 database. Results: Of 33 recurrent COVID-19 patients, 26 were female and 30 were HCW. Mean time to recurrence was 50.5 days which was associated with being a HCW (OR 36.4 (p < 0.0 0 01)), and blood type A (OR 4.8 (p = 0.002)). SARS-CoV-2 antibodies were signifcantly lower in recurrent patients after initial COVID-19 (2.4 ± 0.610; p < 0.0 0 01) and after recurrence (6.4 ± 11.34; p = 0.007). Virus genome sequencing identified reinfection by a different isolate in one patient. Conclusions: This is the first detailed case series showing COVID-19 recurrence with qRT-PCR positivity. For one individual detection of phylogenetically distinct genomic sequences in the first and second episodes confirmed bona fide renfection, but in most cases the data do not formally distinguish between reinfection and re-emergence of a chronic infection reservoir. These episodes were significantly associated with reduced Ab response during initial disease and argue the need for ongoing vigilance without an assumption of protection after a first episode.
Recently, developing bio-based carbon materials due to the surface chemistry and a large spectrum of pore structures have received much attention. In the present work, a series of activated carbon (AC) adsorbents were synthesized from the compost derived by the mechanical/biological treatment of municipal solid wastes and evaluated regarding their CO 2 uptake. The AC samples were characterized by sulfuric acid and calcination by N 2 at 400 and 800°C. Then, the CO 2 uptake capacities were evaluated by dynamic breakthrough experiments in a temperature range of 40-100°C and pressures up to 3 bar. The presented data were properly described by Langmuir model and it was revealed that the CMSW-S-800 sample, treated with sulfuric acid and activated at 800°C, has the highest CO 2 uptake capacity with an amount adsorbed around 2.6 mol/kg at 40°C. In the next step, a mathematical model has been developed to match the experimental dynamic breakthrough data and design a pressure swing adsorption (PSA) cyclic process to evaluate the capacity and potential of the best AC sample for CO 2 adsorption. The results arising from this work showed a possible route for the application of the compost as a source of activated carbon for the sorption of greenhouse gases.
An 11 years-old male mixed-breed cat, with exclusively indoor life, presented 3 cough episodes after the owners tested positive by RT-PCR for SARS-CoV-2. The house is inhabited by 5 people (3 adults and 2 children), and 2 of the adults have shown mild symptoms associated with throat discomfort. The cat was vaccinated, had no history of any previous disease, and tested negative for Feline Coronavirus (FeCoV), Feline Immunodeficiency Virus (FIV) and Feline Leukemia Virus (FeLV). Rectal sample collected from the cat was positive for SARS-CoV-2 by RT-PCR. Viral genome sequences recovered from human and cat samples showed an average 99.4% sequence identity. This is the first report of genome sequences of SARS-CoV-2 recovered from a cat and its owner in Latin America.
We introduce the notion of golden tilings, and we prove a oneto-one correspondence between (i) smooth conjugacy classes of Anosov diffeomorphisms, with an invariant measure absolutely continuous with respect to the Lebesgue measure, (ii) affine classes of golden tilings and (iii) solenoid functions. The solenoid functions give a parametrization of the infinite dimensional space consisting of the mathematical objects described in the above equivalences.
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