Mixed-substituted polyphosphazenes containing carboxylic acid and alkyl ether side groups were synthesized and characterized. Physicochemical properties of phosphazene polyacids in aqueous solutions were investigated as a function of copolymer structure and composition. The immunoadjuvant activity of polyphosphazenes was evaluated by studying the effect of copolymers on the immunogenicity of the influenza virus in mice. Synthesized polyphosphazenes demonstrated the ability to enhance the immune response as compared to the levels elicited by the vaccine alone.

A single-step approach for the synthesis of polyphosphazenes containing sulfonic acid functionalities is developed. Polyphosphazene "sulfonation" is conducted via the direct replacement of chlorine atoms of the macromolecular precursor, poly(dichlorophosphazene), PDCP with a sulfonic acid containing nucleophileshydroxybenzenesulfonic acid. The method makes use of "noncovalent" protection of the sulfonic acid functionality with a hydrophobic ammonium ion, such as the dimethyldipalmitylammonium ion, which then can be easily removed after the completion of the reaction. 1 H, 31 P, and 13 C NMR and size-exclusion HPLC studies revealed no macromolecular byproducts or noticeable degradation of the polyphosphazene backbone under the conditions of the synthesis. Both sulfonated polyphosphazene homopolymers and mixed substituent copolymers containing 4-ethylphenoxy side groups were synthesized and characterized.

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The 1,3-divinyltetramethyldisiloxane−Pt complex (Karstedt catalyst) facilitates copolymerization of α,ω-dienes, such as 1,7-octadiene or 1,5-hexadiene, with 1,3-dihydridotetramethyldisiloxane. Spectroscopic analysis of the copolymers indicates the presence dimethylsiloxy and either 2-octenyl or 2-hexenyl end groups. Apparently, the catalyst not only facilitates the hydrosilylation reaction of 1,3-dihydridotetramethyldisiloxane with terminal C−C double bonds but also catalyzes the isomerization of terminal alkenes to internal alkenes, which are not reactive.

SYNOPSIS Thennooxidatively stable amorphous poly (dicyanopyrazine ether) s with high glass transition temperatures are synthesized and converted into poly ( aryl ether) s bearing covalently bound zinc (11) 2,3,9,10,16,17,23,24-octaphenyltetrapyrazinoporphyrazine units. They are soluble in common organic solvents and can be cast int~ strong and flexible films. The maximum absorption wavelength of the poly (aryl ether) s bearing zinc (11) 2,3,9,10,16,17,23,24-octaphenyltetrapyrazinoporphyrazine units in chloroform is 654 nm. 0 1995 John Wiley & Sons, Inc.