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The purpose of our study was to evaluate the correlation between expression of VEGF, HIF-1α, E-cadherin, and p53 and pathologic stage. We retrospectively reviewed the medical records of the 101 patients who underwent surgery of thyroid nodules from 2000 to 2007. Expression of VEGF, HIF-1α, E-cadherin, and p53 were examinated immunohistochemically. Papillary thyroid carcinoma in this study included 54 cases of more than 45 years old. Each expression of VEGF, HIF-1α, E-cadherin, and p53 was analysed. Only expression loss of E-cadherin was associated with the stage. High HIF-1 expression was significantly associated with VEGF immunoreactivity (p＜0.05). Expression loss of E-cadherin was independent unfavorable factors. It is suggested that high HIF-1α expression may be associated with intratumoral neovascularization possibly through HIF-VEGF pathway.