Melatonin has proven to regenerate the width and length of cortical bone in tibiae rabbits more quickly than collagenized porcine bone. Melatonin acts as a bone stimulator compared with porcine bone and control sites.

Within the limitations of this animal study, topical applications of 5% Melatonin or 10% vitamin D improved bone formation around implants placed immediately after extraction and helped to reduce CBL after 12 weeks osseointegration.

Objectives: To obtain bone "bioreplicas" for determining precisely the amount of biomaterial required for bone regeneration procedure. Study design: A case-control comparison with a total sample size of 20 cases, 10 control and 10 test samples. "Bioreplicas" were generated from helical CAT scans with 0.5 mm slices, without 3D reconstruction or image filters. Bone defects in premolar and molar areas were treated with titanium mesh and xenograft (MP3) combined with resorbable carriers. Time taken to carry out procedures with and without the use of "bioreplicas" (in minutes), discrepancies between the grafts performed with and without "bioreplicas" and bone defects (mm), and postoperative complications were registered. Results: No significant differences were recorded for measurements of width and length of bone defect between patient bone and the biological models. Conclusions: The use of "bioreplicas" obtained by rapid prototyping is effective in treatment planning.