The decline of top carnivores has released large herbivore populations around the world, incurring socioeconomic costs such as increased animal–vehicle collisions. Attempts to control overabundant deer in the Eastern United States have largely failed, and deer–vehicle collisions (DVCs) continue to rise at alarming rates. We present the first valuation of an ecosystem service provided by large carnivore recolonization, using DVC reduction by cougars as a case study. Our coupled deer population models and socioeconomic valuations revealed that cougars could reduce deer densities and DVCs by 22% in the Eastern United States, preventing 21,400 human injuries, 155 fatalities, and $2.13 billion in avoided costs within 30 years of establishment. Recently established cougars in South Dakota prevent $1.1 million in collision costs annually. Large carnivore restoration could provide valuable ecosystem services through such socio‐ecological cascades, and these benefits could offset the societal costs of coexistence.

The instrumentation for a pathfinder mission towards a possible large scale neutrino telescope named "STRings for Absorption length in Water" (STRAW) is presented in terms of design and performance. In June 2018 STRAW was deployed at the Cascadia Basin site operated by Ocean Networks Canada and has been collecting data since then. At a depth of about 2600 meters, the two STRAW 120 meters tall mooring lines are instrumented by three "Precision Optical Calibration Modules" (POCAM) and five Digital Optical Sensors (sDOM). The main objectives of STRAW are the measurement of light extinction in different wavelength bands and bioluminescence at Cascadia Basin. We describe the instrumentation deployed in the Pacific Ocean and show some data from the first measurements.

Background Antibiotic resistance is a global public health threat. Antibiotics are very commonly prescribed for children presenting with uncomplicated lower respiratory tract infections (LRTIs), but there is little evidence from randomised controlled trials of the effectiveness of antibiotics, both overall or among key clinical subgroups. In ARTIC PC, we assessed whether amoxicillin reduces the duration of moderately bad symptoms in children presenting with uncomplicated (non-pneumonic) LRTI in primary care, overall and in key clinical subgroups.Methods ARTIC PC was a double-blind, randomised, placebo-controlled trial done at 56 general practices in England. Eligible children were those aged 6 months to 12 years presenting in primary care with acute uncomplicated LRTI judged to be infective in origin, where pneumonia was not suspected clinically, with symptoms for less than 21 days. Patients were randomly assigned in a 1:1 ratio to receive amoxicillin 50 mg/kg per day or placebo oral suspension, in three divided doses orally for 7 days. Patients and investigators were masked to treatment assignment. The primary outcome was the duration of symptoms rated moderately bad or worse (measured using a validated diary) for up to 28 days or until symptoms resolved. The primary outcome and safety were assessed in the intention-to-treat population. The trial is registered with the ISRCTN Registry (ISRCTN79914298).Findings Between Nov 9, 2016, and March 17, 2020, 432 children (not including six who withdrew permission for use of their data after randomisation) were randomly assigned to the antibiotics group (n=221) or the placebo group (n=211). Complete data for symptom duration were available for 317 (73%) patients; missing data were imputed for the primary analysis. Median durations of moderately bad or worse symptoms were similar between the groups (5 days [IQR 4-11] in the antibiotics group vs 6 days [4-15] in the placebo group; hazard ratio [HR] 1•13 [95% CI 0•90-1•42]). No differences were seen for the primary outcome between the treatment groups in the five prespecified clinical subgroups (patients with chest signs, fever, physician rating of unwell, sputum or chest rattle, and short of breath). Estimates from complete-case analysis and a per-protocol analysis were similar to the imputed data analysis.Interpretation Amoxicillin for uncomplicated chest infections in children is unlikely to be clinically effective either overall or for key subgroups in whom antibiotics are commonly prescribed. Unless pneumonia is suspected, clinicians should provide safety-netting advice but not prescribe antibiotics for most children presenting with chest infections.

Individuals pursuing big-game hunting in the Southwestern United States are presented with a wide array of opportunities, including public lotteries and market-based allocations (e.g., auctions, private transactions). The marketing of big-game hunts and associated services by landowners, guides, and outfitters is increasingly common and supported by state-sanctioned, transferable permit allocations. Given the range of permit and services combinations now available in the market, prices can be expected to vary systematically across attributes of the hunt transaction. Using a sample (n = 942) collected from information posted online and a follow-up telephone survey, this research employed hedonic pricing analysis to examine the regional market for big-game permits and associated hunting services in the Southwest. Estimation results allowed the implicit price of different attributes to be identified. Results also have policy relevance, including: understanding trends in ranch prices, assessing poaching losses, and evaluating the revenue generation of public entities in the regional market.