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A quantitative method based on the disappearance of I 111 laljeled fibrin h;is been used to study the in vivo effect of fibrinolytic agents. Various preparations of human and bovine plasmin were found to lyse clots effectively. The minimal effective dose of human plasmin prepared by the method of Kline was 15 Loomis units/Kg. Plasmin preparations given intravenously produced hypotension and leukopeniii followed by leukocytosis. Doses above 30 Loomis units/Kg, caused decrease in fibrinogen level and clotting index.

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