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Background: Invasive cervical cancer is the commonest cause of cancer morbidity and mortality in South African women. This study provides information on adult women's sexual activity and cervical cancer risk in South Africa.

This article examines recent innovations in how television audiences are measured, paying particular attention to the industry's growing efforts to utilize the large bodies of data generated through social media platforms – a paradigm of research known as Big Data. Although Big Data is considered by many in the television industry as a more veracious model of audience research, this essay uses Boyd and Crawford's (2011) `Six Provocations of Big Data' to problematize and interrogate this prevailing industrial consensus. In doing so, this article explores both the affordances and the limitations of this emerging research paradigm – the latter having largely been ignored by those in the industry – and considers the consequences of these developments for the production culture of television more broadly. Although the full impact of the television industry's adoption of Big Data remains unclear, this article traces some preliminary connections between the introduction of these new measurement practices and the production culture of contemporary television. First, I demonstrate how the design of Big Data privileges real-time analysis, which, in turn, encourages increased investment in ‘live’ and/or ‘event’ television. Second, I argue that despite its potential to produce real-time insights, the scale of Big Data actually limits its utility in the context of the creative industries. Third, building on this discussion of the debatable value and applicability of Big Data, I describe how the introduction of social media metrics is further contributing to a ‘data divide’ in which access to these new information data sets is highly uneven, generally favouring institutions over individuals. Taken together, these three different but overlapping developments provide evidence that the introduction of Big Data is already having a notable effect on the television industry in a number of interesting and unexpected ways.

The relation of acute thrombocytopenic purpura (TP) to the use of drugs was investigated in a case-control study conducted in eastern Massachusetts, Rhode Island, and the Philadelphia region; 62 cases over the age of 16 years with acute onset and with a rapid recovery were compared with 2,625 hospital controls. After control for confounding by multiple logistic regression, use of the following drugs in the week before the onset of symptoms was significantly associated: trimethoprim/sulfamethoxazole (relative risk [RR] estimate, 124), quinidine/quinine (101), dipyridamole (14), sulfonylureas (4.8), and salicylates (2.6). The overall annual incidence of acute TP was estimated to be 18 cases per million population. The excess risks for the associated drugs were estimated to be 38 cases per million users of trimethoprim/sulfamethoxazole per week, 26 per million for quinidine/quinine, 3.9 per million for dipyridamole, 1.2 per million for sulfonylureas, and 0.4 per million for salicylates. Associations with sulfonamides, quinidine/quinine, sulfonylureas, and salicylates have been previously reported, but the present study has provided the first quantitative measures of the risk. The association with dipyridamole was unexpected. In general, despite large RRs, the incidence rates attributable to the drugs at issue (excess risks) were low, suggesting that TP is not an important consideration in the use of the various drugs.

Caspofungin is a member of the echinocandin group of antifungals and inhibits the activity of-glucan synthase thus disrupting cell wall formation and function. While the potent antifungal activity of this agent is well established, this paper analyzed the response of Candida albicans to caspofungin. Exposure of yeast cells to 0.19 μg/ml caspofungin for 1 to 4 h induced nuclear translocation of Cap1p which was confirmed by Western blotting and confocal microscopy. Caspofungin-treated cells demonstrated increased expression of a number of genes associated with the oxidative stress response, including glutathione reductase (GLR1), mitochondrial processing protease (MAS1) and manganese-superoxide dismutase (SOD2) as well as elevated activity of glutathione reductase and superoxide dismutase. Caspofungin treatment also leads to the nuclear localization of Hog1p as visualized by Western blot using anti-phospho-p38 MAPK (Thr180/Tyr182) antibody. This translocation event lead to increased mRNA levels of catalase (CAT1) but not alkyl hydroperoxide reductase (AHP1). The activity of catalase was increased and reached a maximum at 2 h. In addition, pre-exposure of C. albicans to hydrogen peroxide (0.5 mM, 60 min) conferred an increased tolerance to caspofungin. The data presented here highlight the potent antifungal activity of caspofungin and demonstrate that upon exposure to this agent, C. albicans activates the Cap and Hog pathways in an attempt to limit the oxidative and osmotic stresses associated with this drug.