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Background: Diabetic is a chronic metabolic disease with vascular disorder and HDL (High Density Lipoprotein) is a vascular protector acting agent. One of the most difficult complication of diabetics are diabetic foot with often lead to an amputation due to vascular disorder. Objective of this study aims to determine the relationship of HDL levels with diabetic foot severity by comparing HDL levels in each diabetic foot grade according to the Wagner classification.Methods: This is a cross sectional study, with new inpatient and outpatient with diabetic foot ulcer that never received therapy in Wahidin Sudirohusodo Hospital as a study population in April 2018 to June 2018 time period. Frequency distribution, Spearman’s Correlation, Anova, and Chi Square statistical analytic was done with p <0.05 considered as significant.Results: HDL level was wound highest in Grade I and lowest in Grade IV and V. HDL level comparison according to Wagner comparison shows significant difference, p<0.001.Conclusions: There were a negative correlation as an analysis results shows between HDL level and Wagner classification, whereas the lower HDL level, the higher diabetic foot grade and HDL can be used as a prognosis predictor and planning therapy.

ABSTRAKOsteoporosis adalah suatu keadaan dimana massa tulang berkurang sehingga terjadi perubahan mikroarsitektur jaringan yang menyebabkan terjadinya kerapuhan tulang dengan resiko mudah patah. Penelitian ini bertujuan untuk mengetahui hubungan antara indeks massa tubuh dengan osteoporosis pada wanita usia 50-60 tahun. Penelitian ini menggunakan metode penelitian Cross Sectional. Pada penelitian ini dilakukan pengukuran berat badan dan tinggi badan pada 29 subjek, lalu menilai indeks massa tubuhnya. Selanjutnya, dilakukan foto tulang belakang torakolumbal untuk menilai grading osteoporosis menurut Genant. Hasil penelitian menunjukkan bahwa indeks massa tubuh normal paling banyak ditemukan, yaitu 13 sampel (44,8%) dan indeks massa tubuh underweight-obesitas paling sedikit, yaitu masing-masing 5 sampel (17,2%). Untuk grading osteoporosis, grading 0 paling banyak ditemukan, yaitu 15 sampel (51,7%) dan grading 3 paling sedikit, yaitu 2 sampel (6,9%). Dengan demikian, dapat disimpulkan bahwa ada hubungan signifikan antara nilai indeks massa tubuh dengan grading osteoporosis menurut Genant. Semakin tinggi nilai indeks massa tubuh, semakin rendah skor Genant. ABSTRACT Osteoporosis is a condition in which bone mass is reduced so that the tissue microarchitecture changes that lead to the risk of bone fragility fracture easily. This study aims to find out if there is a relationship between Body Mass Index (BMI) and osteoporosis in women of 50-60 years old. This study uses research methods CrossSectional. Assessment of body weight and height was conducted on 29 subjects. The BMI was then determined. The subjects had thoracolumbal rontgen to assess the osteoporosis grading based on Genant method. Most of the subjects (13 or 44.8%) had normal BMI. Only a few samples had underweight and obesity condition (5 samples or 17.2% for each case). As for osteoporosis grading, most of the samples (15 or 51.7%) had 0 grading; and only 2 samples (6.9%) had 3 grading. It can be concluded that there is a significant relationship between BMI, and osteoporosis grading based on Genant method. The higher the BMI, the lower the Genant score will be.

Fracture is defined by the loss of bone or cartilage continuity, either total or partial. Diabetes mellitus (DM) is a group of metabolic diseases characterized by hyperglycaemia resulting from defects in insulin secretion, insulin action, or both. HbA1c could be used as a diagnostic tool and determines the glycaemic control of DM patients. This study aimed to investigate the correlation between serum HbA1c levels and the healing process of postoperative fractures in DM patients. This was an observational study with a retrospective cohort design. The study population was DM patients who were admitted to the Department of Emergency, Dr. Wahidin Sudirohusodo General Hospital, Makassar due to long bone fracture within the period of September 2019-February 2020. The bone fractures healing was evaluated based on the radiographic union scale in tibial fractures (RUST) scores. The results are analysed using the Chi-square test. A total of 70DM patients who underwent fracture reduction surgery were involved in this study. Out of 35 patients with controlled DM (HbA1c <7%), we obtained 24 (68.6%) patients and 11 (31.4%) patients with good and delayed union, respectively. The other 35 patients had uncontrolled DM (HbA1c >7%), and there were 13 (37.1%) patients and 22 (62.9%) patients with good and delayed union, respectively. The Chi-square test showed a significant relationship (p= 0.008). It can be concluded that the increase in HbA1c levels was related to the obstacles in bone fractures healing. Moreover, an infection contributes to the healing status of bone fractures.