Our data suggest that the natural history of the novel C634Y/Y791F double mutation carries a codon 634-like pattern of medullary thyroid carcinoma development, is associated with increased susceptibility to unusually large bilateral pheochromocytomas, and is likely more biologically active than each individual mutation.

To evaluate changes in oral health behavior and the use of dental health services during pregnancy. Material and Methods: This is a crosssectional study nested in a prospective cohort of pregnant women in the city of São Luís, MA. A total of 262 women receiving prenatal care at the Mother-Infant University Hospital were interviewed, through a semi-structured questionnaire, regarding their use of dental services, type of dental treatment received, dietary habits, and oral hygiene before and during pregnancy. The Wilcoxon and McNemar tests (alpha=1%) were used to evaluate the differences in behavior before and during pregnancy. Results: Of the pregnant women evaluated, 33 women (12.6%) reported undergoing at least one dental consultation during their pregnancy. Of these women, 30 (11.4%) had at least one consultation during their first trimester, 10 (3.8%) during their second trimester, and 2 (0.8%) during their third trimester. Preventative and restorative treatments were the most common treatments. There were differences in the behaviors of women related to oral health before and during pregnancy. Subjects reported less frequent daily and post-meal tooth brushing and weekly dental floss and fluoridated mouthwash use during pregnancy compared to prepregnancy (p<0.001). They also reported eating more snacks (p<0.001) and meals (p=0.011) per day during pregnancy compared to prepregnancy. Only the habit of regular sugary food consumption did not vary significantly (p=0.169). Conclusion: There are behavioral changes during pregnancy that can cause dental caries and periodontal disease. Despite these concerns, dental health professionals are not adequately caring for pregnant women. Therefore, public policies incentivizing prenatal dental care are needed.

Forensic dentistry, a branch of the forensic sciences, plays an important role within postmortem human identification, especially in cases of corpses that are charred, skeletonized or in an advanced state of decomposition. Identification of human remains via dental knowledge is done using a comparative technique, which is simple, inexpensive and reliable, the aim of which is to compare dental records and information recorded by dentists in clinical appointments made before an individual's death, with postmortem dental records obtained via forensic examination. In this context, the present study aims to demonstrate the importance of dental records and the effectiveness of forensic dentistry in human identification, illustrated by the report of a case that was conducted at the São Luis Coroner's Office in the Brazilian state of Maranhão. It may be concluded that dental records maintained by a dentist, when complete, properly structured and correctly archived, retain important personal information and are fundamental tools in the process of human identification.

Resumo Em países desenvolvidos, a violência é a principal causa de lesões bucomaxilofaciais (LBMF). No Brasil, há poucas evidências sobre tais lesões. Objetivou-se caracterizar as LBMF resultantes de agressão física em uma capital do nordeste brasileiro e analisar diferenças entre gêneros. Foram investigados 15.847 laudos do Instituto Médico Legal de São Luís/MA, ocorridos em 2012. Coletaram-se dados socioeconômicos, demográficos e características das LBMF. Utilizaram-se os testes Qui-quadrado e Exato de Fisher para avaliar diferenças entre gêneros. Dos casos periciados, 1977 eram LBMF. Vítimas do sexo feminino, com 20-59 anos de idade, cor parda, sem companheiro e empregadas foram mais afetadas. Lesões do tipo equimose, nas regiões bucinadora e labial, decorrentes do uso de instrumentos contundentes, ocasionando debilidade funcional permanente foram mais incidentes em mulheres (P < 0,05), ao passo que fratura dental, ferida contusa e perfurocontusa, decorrentes de instrumentos cortantes e perfurocontundentes, ocasionando deformidade permanente, incapacidade ocupacional e perigo de vida, em homens (P < 0,05). Conclui-se que a incidência de LBMF decorrente de agressão física é alta em São Luís, MA, e, embora as mulheres sejam mais acometidas, as LBMF em homens são mais severas.

The objective was to evaluate the effect of anemia during pregnancy on the risk of dental caries development in pregnant women. A prospective cohort including a sample of pregnant women in a prenatal care unit of São Luís, Brazil, was done. The incidence of dental caries during pregnancy, according to Nyvad's criteria, was the outcome. The main independent variables were serum iron, ferritin, hemoglobin, erythrocyte, hematocrit, mean corpuscular volume (MCV), mean corpuscular hemoglobin (MCH), mean corpuscular hemoglobin concentration (MCHC), and red cell distribution width (RDW). Pregnant women (n = 121) were evaluated at two moments: up to 16th week of gestational age (T1) and in the last trimester of pregnancy (T2). Crude and adjusted associations were estimated by the incidence ratio risk (IRR) and respective 95% confidence intervals (95%CI). After adjustment, higher serum concentrations of ferritin (IRR = 0.97, 95%CI 0.95-0.99) in T1, and Fe (IRR = 0.99, 95%CI 0.98-0.99), ferritin (IRR = 0.99, 95%CI 0.98-0.99), erythrocyte (IRR = 0.71, 95%CI 0.50-0.99), hemoglobin (IRR = 0.84, 95%CI 0.73-0.96), hematocrit (IRR = 0.93, 95%CI 0.88-0.98), MCV (IRR = 0.91, 95%CI 0.86-0.96), and MCH (IRR = 0.83, 95%CI 0.74-0.93) in T2, were associated with fewer incidence of dental caries in pregnant women. Iron deficiency anemia during pregnancy is a risk factor for the incidence of dental caries in these women.