ResUmoObjetivo: Revisar os conhecimentos existentes em relação ao uso de fatores de crescimento epidérmico e estimulador de colônias de granulócitos na prevenção e/ou no tratamento da enterocolite necrosante (ECN) durante o período neonatal. Fontes de dados:Revisão da literatura, nas bases de dados Medline, Lilacs, SciELO e PubMed, utilizando os unitermos "recém-nascidos", "enterocolite" e "fatores de crescimento", no período de 2003 a 2007. Nesta busca, 49 artigos foram encontrados, sendo 17 pertinentes ao tema. Também foram utilizados outros artigos, independente do ano de publicação, relacionados a aspectos definidores da ECN no recém-nascido.Síntese dos dados: A ECN continua sendo responsável por uma elevada morbimortalidade neonatal. Os mecanismos fisiopatológicos vêm sendo elucidados e, a partir deles, são discutidas novas terapias, como o uso de fatores de crescimento, destacando-se o fator de crescimento epidérmico e o fator estimulador de colônias de granulócitos.Conclusões: O uso de fatores de crescimento no tratamento e prevenção da ECN neonatal parece promissor. É necessário maior número de ensaios clínicos para comprovar sua eficácia e segurança. Enquanto isso, a melhor prática médica continua sendo a prevenção da doença.Palavras-chave: recém-nascido; dietoterapia; fatores de crescimento; enterocolite necrosante. Data sources: Literature review of Medline, Lilacs, SciELO and Pubmed databases, using the key-words "newborn", "enterocolitis" and "growth factors", from 2003 to 2007. Fourty-nine papers were retrieved, but only 17 related to the subject. Other studies that described some clinical aspects of enterocolitis were also included, regardless of the year of publication.Data synthesis: Necrotizing and enterocolitis has been an important cause of morbidity and mortality in the neonatal period. As the knowledge about the pathophysiology of this disease improves, new therapies, such as the administration of epidermal growth factor and granulocyte colony-stimulating factor, are being discussed.Conclusions: The use of growth factors for treatment and prevention of NEC seems promising. However, further clinics assays are needed to evaluate the effectiveness and the safety of these growth factors. At this moment, the best clinical practice is the prevention of the disease.Key-words: infant, newborn; diet therapy; growth factors; enterocolitis, necrotizing.
Background:The emollients are important ingredients used in skincare formulations that can act as moisturizing agents through their occlusive potential, preventing skin water loss. Consumer interest in natural and sustainable products has grown considerably in the last few years, requiring efforts from the cosmetic industry to design products with raw materials of natural, organic, and sustainable origin. Thus, it is essential to improve the knowledge about the behavior of cosmetic raw materials that can be used as sustainable alternatives to synthetic ingredients.Aim: This work aimed to evaluate the occlusive performance of different vegetable oils used as emollients in skincare cosmetics, through comparative analysis with petrolatum, a synthetic emollient with a high occlusive skin potential. Method:The study included 80 healthy female adult volunteers. TEWL measurements were performed before and after 15 min, 2 and 6 h of emollients application on the forearms of the research participants. All research participants provided written informed consent. Results:The results obtained showed that the vegetable oils were effective in providing an occlusive effect on the skin. When compared to the petrolatum, the vegetable oils did not provide a high immediate skin occlusion effect. However, most of them showed a skin occlusion performance comparable to petrolatum throughout the 6 h time course. Conclusion:Vegetable oils can be used as a sustainable alternative to synthetic emollients, and they are promising in replacing petrolatum in skincare formulations with respect to the occlusion effect of the skin. The vegetable oils did not provide a high immediate skin occlusion effect (15 min post-application) as the petrolatum, which is known to have increased occlusion properties. However, most of them showed a skin occlusion performance comparable to petrolatum throughout the 6-hour time course.
Objetivou-se descrever as estratégias e formas de análise, planejamento e monitoramento do Comitê de Prevenção de Mortalidade Materna, Perinatal e Infantil para a prevenção do óbito materno, infantil e fetal no município de Sobral, Ceará. Trata-se de um estudo qualitativo de sistematização da experiência vivenciada, sob a perspectiva da observação participante. O Comitê teve um total de 643 óbitos infantis investigados de 2006 a 2021, e essa avaliação dos óbitos trouxe evidências das causas e problemas no acesso e/ou na qualidade da assistência no pré-natal ou no parto à mãe e à criança, reduzindo assim a Taxa de Mortalidade Infantil. A vigilância do óbito realizada de forma sistemática e integrada aos diferentes setores permite a construção de indicadores para o monitoramento. A experiência vivenciada evidenciou as atividades organizacionais do Comitê quanto à evitabilidade dos óbitos maternos, infantis e fetais. Os dados aqui apontados corroboram a necessidade de ampliar o olhar para a atenção materno-infantil, buscando alternativas que viabilizem uma assistência cada vez mais qualificada à gestante, puérpera e criança.
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