The EpHLA software is an accurate and quick method for the identification of AMMs and thus it may be a very useful tool in the decision-making process of organ allocation for highly sensitized patients as well as in many other applications.

Objetivo: Perquirir acerca da regulamentação das relações de trabalho na enfermagem e refletir sobre os aspectos jurídicos de sua jornada de trabalho. Metodologia: Trata-se de um estudo reflexivo, que analisou as relações de trabalho da equipe de enfermagem com foco em sua jornada de trabalho, com um olhar direcionado aos aspectos jurídicos que envolvem a temática. Resultados: A equipe de enfermagem não dispõe de proteção legal específica acerca de sua jornada de trabalho, apesar de desenvolver um trabalho essencial à vida e de estar presente na quase totalidade das instituições de saúde. A população tem direito de ser atendida por profissionais competentes e saudáveis, tendo em vista que a assistência segura e de qualidade, além de moralmente requerida, é mais econômica, pois evita danos e reduz ações judiciais contra os serviços de saúde. Para tanto surge a discussão sobre o Projeto de Lei 2.295/2000, que defende carga horária de 30 horas semanais, refletindo uma conquista histórica da classe de enfermagem, que se fundamenta em aspectos biológicos, sociais e econômicos.CONSIDERAÇÕES FINAIS: A redução da jornada de trabalho permite a prestação de uma assistência mais segura e representa nada mais que a concretização do arcabouço jurídico protecionista vigente. Descritores: Jornada de trabalho. Enfermagem. Saúde do Trabalhador.

Background Congenital syndrome of Zika virus (CSZV) is associated with neuromotor and cognitive developmental disorders, limiting the independence and autonomy of affected children and high susceptibility to complications, so palliative care needs to be discussed and applied. Aim To identify factors associated with emergency visits and hospitalizations of patients with CSZV and clinical interventions performed from the perspective of palliative care. Design This is a cross-sectional study with bidirectional longitudinal component. Data were collected between May and October 2017 through the review of medical records and interviews with relatives of patients hospitalized. Setting/Participants The study was developed in a tertiary care hospital involving patients with confirmed CSZV born as of August 2015 and followed up until October 2017. Patients under investigation were excluded. Results 145 patients were followed up at the specialized outpatient clinic, 92 (63.5%) were consulted at least once in the emergency room, and 49% had already been hospitalized, with the main reason being neurological causes, while 24.1% had never required any emergency visit or hospitalization. No risk factors were associated with the occurrence of consultations or hospitalizations. Such events happened at an early age and were accompanied by a high number of invasive procedures and interventions. An approach in palliative care was only identified in two hospitalized patients. Conclusions For the patient with known severe malformations caused by congenital infection by the Zika virus with indication of palliative care, this approach could be used in order to allow life without suffering and disproportionate invasive method.

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Background COVID-19 convalescent plasma (CCP) was used in the early period of the pandemic, but the effectivity of this treatment showed different results, especially because of the possible ineffectiveness of passive antibodies, when an inflammatory response is already established. Objectives: The aim of this study is to compare the outcomes of two different cohorts of COVID-19 patients that received CCP transfusion in the years 2020 and 2021. Design and setting: This is a retrospective study from a tertiary hospital in São Paulo, Brazil. Methods: We included a retrospective cohort of patients that received convalescent compassionate plasma and another group with patients from a previous clinical study. We collected clinical and laboratory data on the day of transfusion and five days later. Patients with hematological or immunological conditions were excluded. A p-value < 0·05 was considered significant.Results CCP did not show to interfere in the outcomes of severe COVID-19 patients, when comparing two different cohorts transfused with different volumes and titles of neutralizing antibodies. Despite the improvement in some laboratory parameters, there was not impact on clinical outcomes. Dialysis had a negative impact on the ICU stay, days of hospitalization and days of mechanical ventilation. Each higher point on the day 0 WHO scale reduced the probability of hospital and ICU discharge, and the risk of mechanical ventilation discontinuation. Conclusions: In conclusion, the use of dialysis and the assessed clinical severity represented by WHO scale on day 0 had influence on the outcomes, but not the CCP transfusion.