RESUMO Objetivo: Analisar as práticas profissionais das equipes dos Núcleos de Apoio à Saúde da Família (NASF) dos municípios de Campina Grande e João Pessoa, em consonância com os modelos de apoio matricial identificados. Metodologia: Realizou-se observação não-participante junto aos profissionais do NASF de Campina Grande e João Pessoa, em um total de 480 horas, em que puderam ser observadas capacitações promovidas pela Secretaria Estadual de Saúde e Ministério da Saúde para as equipes NASF, reuniões entre equipe e gestores, além de atividades cotidianas das equipes. Foram realizadas também entrevistas semi-estruturadas com 36 profissionais, coordenação geral do NASF e dois gerentes distritais. Resultados: Identificaram-se cinco acepções de apoio: o gerencial-administrativo, que busca solucionar problemas burocráticos das unidades de saúde e exercer funções burocráticas; o político-institucional que opera os direcionamentos políticos defendidos pela gestão na condução das ações de saúde; o técnico-pedagógico, que promove processos de educação permanente junto às equipes, com intuito de conferir maior resolubilidade aos problemas de saúde pertinentes; o técnico-assistencial que oferta atendimentos diretos aos usuários; e o político-comunitário que fortalece a organização política da comunidade. Conclusão: A assunção de uma ou mais concepções de apoio matricial por uma gestão não ocorre apenas por opção técnica, mas é influenciada por uma variedade de fatores políticos e econômicos que influenciam a adoção de um determinado modelo técnicoassistencial em saúde.

Background Adverse drug reactions (ADRs) are the sixth leading causes of death worldwide; monitoring them is fundamental, especially in patients with disorders like chronic rheumatic diseases (CRDs). The study aimed to describe the ADRs investigating their severity and associated factors and resulting interventions in pediatric patients with CRDs. Methods A retrospective, descriptive and analytical study was conducted on a cohort of children and adolescents with juvenile idiopathic arthritis (JIA), juvenile systemic lupus erythematosus (JSLE) and juvenile dermatomyositis (JDM). The study evaluated medical records of the patients to determine the causality and the management of ADRs. In order to investigate the risk factors that would increase the risk of ADRs, a logistic regression model was carried out on a group of patients treated with the main used drug. Results We observed 949 ADRs in 547 patients studied. Methotrexate (MTX) was the most frequently used medication and also the cause of the most ADRs, which occurred in 63.3% of patients, followed by glucocorticoids (GCs). Comparing synthetic disease-modifying anti-rheumatic drugs (sDMARDs) vs biologic disease-modifying anti-rheumatic drugs (bDMARDs), the ADRs attributed to the former were by far higher than the latter. In general, the severity of ADRs was moderate and manageable. Drug withdrawal occurred in almost a quarter of the cases. In terms of risk factors, most patients who experienced ADRs due to MTX, were 16 years old or younger and received MTX in doses equal or higher than 0.6 mg/kg/week. Patients with JIA and JDM had a lower risk of ADRs than patients with JSLE. In the multiple regression model, the use of GCs for over 6 months led to an increase of 0.5% in the number of ADRs. Conclusions Although the ADRs highly likely affect a wide range of children and adolescents with CRDs they were considered moderate and manageable cases mostly. However, triggers of ADRs need further investigations.

Background Congenital syndrome of Zika virus (CSZV) is associated with neuromotor and cognitive developmental disorders, limiting the independence and autonomy of affected children and high susceptibility to complications, so palliative care needs to be discussed and applied. Aim To identify factors associated with emergency visits and hospitalizations of patients with CSZV and clinical interventions performed from the perspective of palliative care. Design This is a cross-sectional study with bidirectional longitudinal component. Data were collected between May and October 2017 through the review of medical records and interviews with relatives of patients hospitalized. Setting/Participants The study was developed in a tertiary care hospital involving patients with confirmed CSZV born as of August 2015 and followed up until October 2017. Patients under investigation were excluded. Results 145 patients were followed up at the specialized outpatient clinic, 92 (63.5%) were consulted at least once in the emergency room, and 49% had already been hospitalized, with the main reason being neurological causes, while 24.1% had never required any emergency visit or hospitalization. No risk factors were associated with the occurrence of consultations or hospitalizations. Such events happened at an early age and were accompanied by a high number of invasive procedures and interventions. An approach in palliative care was only identified in two hospitalized patients. Conclusions For the patient with known severe malformations caused by congenital infection by the Zika virus with indication of palliative care, this approach could be used in order to allow life without suffering and disproportionate invasive method.

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