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An interesting and facile physical route is proposed to fabricate multi-elemental alloyed nanoparticle arrays with controllable size, composition and periodicity.

Thermoradiotherapy acts as an important antitumor modality because heating can increase the blood flow and improve the oxygen level in tumor, thus remission of hypoxia-associated resistance for radiotherapy (RT). However, most agents for thermoradiotherapy are used either in the first nearinfrared biological window or low photothermal conversion efficiency. Here, a facile method to prepare Cu x S/Au nanocomposites via reduction methods from Cu x S templates in mild synthetic conditions (i.e., aqueous solution and room temperature) is presented. After the growth of Au nanoparticles, the Cu x S/Au nanocomposites have greater benefits for photothermal efficiency than that of Cu x S nanoparticles due to the enhanced absorbance in the second near-infrared window. Moreover, biocompatibility and stability of these nanocomposites are greatly improved by lipoic acid poly(ethylene glycol). After the tumors were irradiated with a 1064 nm laser, their oxygenation status is subsequently improved, and the combination of photothermal therapy and RT achieves remarkable synergistic therapeutic effects. This work provides a novel idea to design a new-generation nanomedicine for tumor thermoradiotherapy.

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