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Drug carrier networks are sophisticated because pharmaceutical scientists gain a greater understanding of the performance of biochemical as well as physicochemical parameters. Oral disintegrating tablets (ODTs) are now more commonly available for the treatment of various diseases than other products. Due to its convenience in terms of manufacture and administration, the oral administration route is being studied as the most utilized route. ODTs, particularly for pediatric patients, are considered to be effective drug-delivery systems due to their quick disintegration properties, water-free usage, and ease of swallowing. ‘Orally disintegrating tablets’ are present in solid dosage forms that dissolve in the mouth in less than 60 s without the need for water. Rapid tablet disintegration leads to rapid dissolution and therefore rapid action. ODTs are an ideal treatment for specific populations such as unconscious patients, bedridden patients, dysphagic patients, psychotic patients, geriatric patients, pediatric patients, and young patients with underdeveloped nervous and muscular systems. The main aim of this research paper is to discuss the advantages, drawbacks, formulation problems, manufacturing methods, patented technology, evaluation tests, and marketed formulations of ODTs, their value, different technologies, ideal characteristics, and aspects of formulation and design, future perspectives, and marketed preparations, particularly for pediatric patients.

Acute generalized exanthematous pustulosis (AGEP) is a rare cutaneous adverse drug reaction characterized by rapid occurrence of dozens to thousands pinhead-sized, non-follicular, sterile pustular eruptions. AGEP is infrequent with an incidence of one to five millions per year. There are only two previous reports of paracetamol induced AGEP in literature. The clinical course of AGEP is characterised by spontaneous resolution on drug withdrawal. Resolution is marked by a characteristic desquamation. Diagnosis of AGEP depends on morphology of skin lesions, presence of fever, laboratory and histopathological findings. Factors that favours the diagnosis of AGEP include onset of pustules within few hours or in few days after the causative agent is administered. The most frequent causative drugs are Aminopenicillins, ampicillin, amoxixillin, sulphonamides, pristinamycin, quinolones, hydroxychloroquine, terbinafin diltiazem. In some cases it is induced by bacterial, viral or parasitic infections. In our case, a 50 year male patient developed multiple pus filled lesions, burning sensations all over the body caused by administering paracetamol drug where, the lesions desiccated immediately after cessation of offending drug in two daysleaving exfoliations .Upon diagnosis the white blood cell count was increased indicating lymphocytosis. He was administered with antihistamines, emollients and corticosteroids during his course of stay in hospital. Pustular rashes were reduced and patient recovered with treatment. Paracetamol is one of the most widely used safer drug worldwide, herein draws special attention that no drug is completely safe hence proper medication history interview would be recommended to overcome the drugs causing adverse drug reactions, that can be possibly dangerous and life threatening.

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Scrub typhus is caused by Orientia tsutsugamushi and is transmitted to humans by an arthropod vector of the Thrombiculidae family. It is one of the most common re-emerging ricketssial infection in India and other South east Asian countries. Nearly a billion people are at risk with at least a million cases being reported from this region every year. It is distributed in the tsutsugamushi triangle which is distributed over a wide area of 13 million km 2 . Eschar is the characteristic lesion that starts as a vesicular lesion at the site of mite feeding. It is present in about 40% of cases. It progresses to an ulcer with black necrotic center and an erythematous border along with regional lymphadenopathy. It may affect the central nervous system, cardiovascular system, renal and gastrointestinal system. Here we report three cases which depict the atypical presentations of this disease. It is an eye-opener for clinicians to keep this as a provisional diagnosis in patients who present with fever of unknown origin. ………………………………………………………………………………………………………………………………...