Oral disintegrating tablets

Abstract

Drug carrier networks are sophisticated because pharmaceutical scientists gain a greater understanding of the performance of biochemical as well as physicochemical parameters. Oral disintegrating tablets (ODTs) are now more commonly available for the treatment of various diseases than other products. Due to its convenience in terms of manufacture and administration, the oral administration route is being studied as the most utilized route. ODTs, particularly for pediatric patients, are considered to be effective drug-delivery systems due to their quick disintegration properties, water-free usage, and ease of swallowing. ‘Orally disintegrating tablets’ are present in solid dosage forms that dissolve in the mouth in less than 60 s without the need for water. Rapid tablet disintegration leads to rapid dissolution and therefore rapid action. ODTs are an ideal treatment for specific populations such as unconscious patients, bedridden patients, dysphagic patients, psychotic patients, geriatric patients, pediatric patients, and young patients with underdeveloped nervous and muscular systems. The main aim of this research paper is to discuss the advantages, drawbacks, formulation problems, manufacturing methods, patented technology, evaluation tests, and marketed formulations of ODTs, their value, different technologies, ideal characteristics, and aspects of formulation and design, future perspectives, and marketed preparations, particularly for pediatric patients.

Fabrication of Sublingual Alprazolam Wafers using Mucoadhesive Vigna mungo L. Seeds and Characterized with Texture Analyzer QTS-25

“…Within 30-50 seconds after delivery, the wafer disintegrates completely. 6 Alprazolam (8-chloro-1-methyl-6-phenyl-4H-l,2,4, triazolo[4,3-α] 1,4 benzodiazepine) 7 , a central nervous system active compound, has clinical effectualness in treating Generalized Anxiety Disorder (GAD) 8 and used for the management of the panic disorder in presence or absence of phobic neurosis. For managing these disorders, rapid onset of drug action is desirable and achieved by parenteral administration of alprazolam, but this route is hazardous for various reasons.…”

Acute and Sub-Acute Toxicity Studies of Starch Hyaluronate in Wistar Rats

“…Superdisintegrants are compounds that were added to fastdissolving tablets to enhance the tablet's disintegration process. 1 A variety of excipients have been frequently used as tablet disintegrants for some years, and only a few recognized disintegrants are already available to pharmaceutical industry formulators. Simple starches are among the most commonly used disintegrants.…”