No abstract

Aims of the study:To evaluate the expression of the Bcl-2 oncoprotein in patients with primary breast cancer, to correlate it with estrogen and progesterone receptors and various prognostic parameters. Patients and methods: Fifty two cases of primary breast cancer in which the estrogen and progesterone receptors statuses were previously tested by immuno-histochemical staining, were included in this retrospective study. The cases were collected from Al-Jamhori Teaching Hospital, Nineveh Private Hospital and Private laboratories. The expression of Bcl-2 oncoprotein was evaluated immunohistochemically; the findings were correlated with the estrogen and progesterone receptors, the age of the patients, size, type and grade of the tumor, lymph node status and vascular invasion. Results: Bcl-2 oncoprotein was detected in 24 cases of primary breast cancer (46.2%). In this study the majority of estrogen and progesterone receptors positive cases, (87.5%) and (83.3%) respectively, showed positive Bcl-2 oncoprotein expression, (P<0.001) and (P=0.0002) respectively. A significant association was found between Bcl-2 and tumor type (P=0.017). Bcl-2 oncoprotein was directly correlated with the age of the patients (P=0.0047), and inversely with the grade of the tumor and vascular invasion (P value = 0.0092, <0.001) respectively. No significant correlation with tumor size nor with lymph node status could be found, (P=0.078) and (P=0.19) respectively. Conclusions: Bcl-2 oncoprotein was positive in 46.2% of primary breast cancer. This study revealed a significantly direct correlation between the Bcl-2 and the estrogen and progesterone receptors. A significant association was found between Bcl-2 oncoprotein and tumor type. Bcl-2 was directly related to the age of the patients, and inversely related to the grade of the tumor and vascular invasion.

LDH activity in gastric juice was high in all cases of carcinoma of the stomach investigated provided that the pH of the resting gastric juice was above 5·0. No LDH activity could be detected in gastric aspirate, whether from patients with carcinoma of the stomach or not, when the pH of the resting juice was below 5·0. LDH activity in gastric juice is rapidly and irreversibly inactivated by hydrochloric acid at a pH of 4·5 to 5·0.

No abstract

No abstract