The main objectives of the KM3NeT Collaboration are (i) the discovery and subsequent observation of high-energy neutrino sources in the Universe and (ii) the determination of the mass hierarchy of neutrinos. These objectives are strongly motivated by two recent important discoveries, namely: (1) the highenergy astrophysical neutrino signal reported by IceCube and (2) the sizable contribution of electron neutrinos to the third neutrino mass eigenstate as reported by Daya Bay, Reno and others. To meet these objectives, the KM3NeT Collaboration plans to build a new Research Infrastructure consisting of a network of deep-sea neutrino telescopes in the Mediterranean Sea. A phased and distributed implementation is pursued which maximises the access to regional funds, the availability of human resources and the synergistic opportunities for the Earth and sea sciences community. Three suitable deep-sea sites are selected, namely off-shore Toulon (France), Capo Passero (Sicily, Italy) and Pylos (Peloponnese, Greece). The infrastructure will consist of three so-called building blocks. A building block comprises 115 strings, each string comprises 18 optical modules and each optical module comprises 31 photo-multiplier tubes. Each building block thus constitutes a threedimensional array of photo sensors that can be used to detect the Cherenkov light produced by relativistic particles emerging from neutrino interactions. Two building blocks will be sparsely configured to fully explore the IceCube signal with similar instrumented volume, different methodology, improved resolution and complementary field of view, including the galactic plane. One building block will be densely configured to precisely measure atmospheric neutrino oscillations.

Abstract. Bearing on the model for the time-dependent metagalactic radiation field developed in the first paper of this series, we compute the gamma-ray attenuation due to pair production in photon-photon scattering. Emphasis is on the effects of varying the star formation rate and the fraction of UV radiation assumed to escape from the star forming regions, the latter being important mainly for high-redshift sources. Conversely, we investigate how the metagalactic radiation field can be measured from the gamma-ray pair creation cutoff as a function of redshift, the Fazio-Stecker relation. For three observed TeV-blazars (Mkn 501, Mkn 421, H1426+428) we study the effects of gamma-ray attenuation on their spectra in detail.

Previous detections of individual astrophysical sources of neutrinos are limited to the Sun and the supernova 1987A, whereas the origins of the diffuse flux of high-energy cosmic neutrinos remain unidentified. On 22 September 2017, we detected a high-energy neutrino, IceCube-170922A, with an energy of ~290 tera-electron volts. Its arrival direction was consistent with the location of a known γ-ray blazar, TXS 0506+056, observed to be in a flaring state. An extensive multiwavelength campaign followed, ranging from radio frequencies to γ-rays. These observations characterize the variability and energetics of the blazar and include the detection of TXS 0506+056 in very-high-energy γ-rays. This observation of a neutrino in spatial coincidence with a γ-ray-emitting blazar during an active phase suggests that blazars may be a source of high-energy neutrinos.

The blazar Mrk 501 was observed at energies above 0.10 TeV with the MAGIC Telescope from 2005 May through July. The high sensitivity of the instrument enabled the determination of the flux and spectrum of the source on a night-by-night basis. Throughout our observational campaign, the flux from Mrk 501 was found to vary by an order of magnitude. Intranight flux variability with flux-doubling times down to 2 minutes was observed during the two most active nights, namely, June 30 and July 9. These are the fastest flux variations ever observed in Mrk 501. The similar to 20 minute long flare of July 9 showed an indication of a 4 +/- 1 minute time delay between the peaks of F(< 0.25 TeV) and F(> 1.2 TeV), which may indicate a progressive acceleration of electrons in the emitting plasma blob. The flux variability was quantified for several energy ranges and found to increase with the energy of the gamma-ray photons. The spectra hardened significantly with increasing flux, and during the two most active nights, a spectral peak was clearly detected at 0.43 +/- 0.06 and 0.25 +/- 0.07 TeV, respectively, for June 30 and July 9. There is no evidence of such a spectral feature for the other nights at energies down to 0.10 TeV, thus suggesting that the spectral peak is correlated with the source luminosity. These observed characteristics could be accommodated in a synchrotron self-Compton framework in which the increase in gamma-ray flux is produced by a freshly injected ( high energy) electron population

We obtain the maximum diffuse neutrino intensity predicted by hadronic photoproduction models of the type which have been applied to the jets of active galactic nuclei or gamma ray bursts. For this, we compare the proton and gamma ray fluxes associated with hadronic photoproduction in extragalactic neutrino sources with the present experimental upper limit on cosmic ray protons and the extragalactic gamma ray background, employing a transport calculation of energetic protons traversing cosmic photon backgrounds. We take into account the effects of the photon spectral shape in the sources on the photoproduction process, cosmological source evolution, the optical depth for cosmic ray ejection, and discuss the possible effects of magnetic fields in the vicinity of the sources. For photohadronic neutrino sources which are optically thin to the emission of neutrons we find that the cosmic ray flux imposes a stronger bound than the extragalactic gamma ray background in the energy range between 10 5 GeV and 10 11 GeV, as previously noted by Waxman & Bahcall 1 . We also determine the maximum contribution from the jets of active galactic nuclei, using constraints set to their neutron opacity by gamma-ray observations. This present upper limit is consistent with the jets of active galactic nuclei producing the extragalactic gamma ray background hadronically, but we point out future observations in the GeV-to-TeV regime could lower this limit. We also briefly discuss the contribution of gamma ray bursts to ultra-high energy cosmic rays as it can be inferred from possible observations or limits on their correlated neutrino fluxes.